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Synthetic biology

Two-for-one designer labels

Nature Chemistry volume 6, pages 379381 (2014) | Download Citation

Labelling of proteins with pairs of fluorophores enables their conformations to be studied; however, complete incorporation of labels in multiple, pre-defined locations is very difficult. Now, a combination of double unnatural amino acid mutagenesis and selective chemical modification offers a general method to achieve this.

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Affiliations

  1. E. James Petersson and John B. Warner are at the Department of Chemistry, University of Pennsylvania, 231 South 34th Street, Philadelphia, Pennsylvania 19104-6323, USA

    • E. James Petersson
    •  & John B. Warner

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Correspondence to E. James Petersson.

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DOI

https://doi.org/10.1038/nchem.1935

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