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Protein folding

When ribosomes pick the structure


Anfinsen's principle tells us that the folded structure of a protein is determined solely by its sequence. Now, it has been shown that the rate at which a polypeptide chain is synthesized in the cell can affect which of two alternative folded structures it adopts.

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Figure 1: Protein folding scenarios described by Clark and co-workers4 for polypeptide YKB.


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Correspondence to Laura S. Itzhaki.

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Sivertsson, E., Itzhaki, L. When ribosomes pick the structure. Nature Chem 6, 378–379 (2014).

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