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Protein folding

When ribosomes pick the structure

Nature Chemistry volume 6, pages 378379 (2014) | Download Citation

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Anfinsen's principle tells us that the folded structure of a protein is determined solely by its sequence. Now, it has been shown that the rate at which a polypeptide chain is synthesized in the cell can affect which of two alternative folded structures it adopts.

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Affiliations

  1. Elin M. Sivertsson and Laura S. Itzhaki are in the Department of Pharmacology at the University of Cambridge, Tennis Court Road, Cambridge, CB2 1PD, UK

    • Elin M. Sivertsson
    •  & Laura S. Itzhaki

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Correspondence to Laura S. Itzhaki.

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DOI

https://doi.org/10.1038/nchem.1926

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