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Total synthesis

A cascade of new antibiotics

The total synthesis of a bisanthraquinone natural product provides the opportunity to investigate the medicinal properties of a new class of antibiotics.

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Figure 1: The total synthesis of (+)-BE43472B.

References

  1. Nicolaou, K. C., Lin, Y. H. & Becker, J. Angew. Chem. Int. Ed. doi:10.1002/anie.200900058 (2009).

  2. Bentley, S. D. et al. Nature 417, 141–147 (2002).

    Article  Google Scholar 

  3. Ikeda, H. et al. Nature Biotechnol. 21, 526–531 (2003).

    Article  Google Scholar 

  4. Fenical, W. & Jensen, P. R. Nature Chem. Biol. 2, 666–673 (2006).

    Article  CAS  Google Scholar 

  5. Corey, E. J. et al. J. Am. Chem. Soc. 100, 4620–4622 (1978).

    Article  CAS  Google Scholar 

  6. Newman, D. J. & Cragg, G. M. J. Nat. Prod. 70, 461–477 (2007).

    Article  CAS  Google Scholar 

  7. Kushida, H. et al. Antitumoric BE43472 manufacture with Strptomyces. JPO patent 8,143,569 (1996).

  8. Socha, A. M. et al. J. Nat. Prod. 69, 1070–1073 (2006).

    Article  CAS  Google Scholar 

  9. Socha, A. M. et al. Bioorg. Med. Chem. 14, 8446–8454 (2006).

    Article  CAS  Google Scholar 

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Rowley, D. A cascade of new antibiotics. Nature Chem 1, 110–112 (2009). https://doi.org/10.1038/nchem.192

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