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Total synthesis

Welwitindolinone is well worth it

Recent syntheses of the natural product 3-hydroxy-N-methylwelwitindolinone C isothiocyanate are taken as examples to answer an oft-raised question about the value of total synthesis.

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Figure 1
Figure 2: Competing synthetic routes to 3-hydroxy-N-methylwelwitindolinone C isothiocyanate.


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Correspondence to John L. Wood.

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Wood, J. Welwitindolinone is well worth it. Nature Chem 4, 341–343 (2012).

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