Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Temporary intramolecularity

A simple aldehyde has been shown to catalyse an intermolecular hydroamination, not by activating either reaction partner, but simply by bringing them into close proximity.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.

Figure 1: Coming together.


  1. Laidler, K. J. & King, M. C. J. Phys. Chem. 87, 2657–2664 (1983).

    Article  CAS  Google Scholar 

  2. Page, M. I. & Jencks, W. P. Proc. Natl Acad. Sci. USA 68, 1678–1683 (1971).

    Article  CAS  Google Scholar 

  3. Tan, K. L. ACS Catalysis 1, 877–886 (2011).

    Article  CAS  Google Scholar 

  4. MacDonald, M. J., Schipper, D. J., Ng, P. J., Moran, J. & Beauchemin, A. M. J. Am. Chem. Soc. 133, 20100–20103 (2011).

    Article  CAS  Google Scholar 

  5. Diederich, F. & Stang, P. J. Templated Organic Synthesis (Wiley-VCH, 2000).

    Google Scholar 

  6. Pascal, R., Lasperas, M., Taillades, J. & Commeyras, A. New. J. Chem. 11, 235–244 (1987).

    CAS  Google Scholar 

  7. Cooper, N. J. & Knight, D. W. Tetrahedron 60, 243–269 (2004).

    Article  CAS  Google Scholar 

  8. Bell, K. E., Coogan, M. P., Gravestock, M. B., Knight, D. W. & Thornton, S. R. 38, 8545–8548 (1997).

  9. Rousseau, G. & Breit, B. Angew. Chem. Int. Ed. 50, 2450–2494 (2011).

    Article  CAS  Google Scholar 

  10. Sun, X., Worthy, A. D. & Tan, K. L. Angew. Chem. Int. Ed. 50, 8167–8171 (2011).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Kian L. Tan.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Tan, K. Temporary intramolecularity. Nature Chem 4, 253–254 (2012).

Download citation

  • Published:

  • Issue Date:

  • DOI:

This article is cited by


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing