Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Do not bury thirty years of avoidance findings

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

References

  1. 1

    LeDoux JE, Moscarello J, Sears R, Campese V . The birth, death and resurrection of avoidance: a reconceptualization of a troubled paradigm. Mol Psychiatry 2017; 22: 24–36.

    CAS  Article  Google Scholar 

  2. 2

    Fernandez-Teruel A, Escorihuela RM, Núñez JF, Zapata A, Boix F, Salazar W et al. The early acquisition of two-way (shuttle-box) avoidance as an anxiety-mediated behavior: psychopharmacological validation. Brain Res Bull 1991; 26: 173–176.

    CAS  Article  Google Scholar 

  3. 3

    Escorihuela RM, Tobeña A, Driscoll P, Fernandez-Teruel A . Effects of training, early handling, and perinatal flumazenil on shuttle box acquisition in Roman low-avoidance rats: toward overcoming a genetic deficit. Neurosci Biobehav Rev 1995; 19: 353–367.

    CAS  Article  Google Scholar 

  4. 4

    Vicens-Costa E, Martinez-Membrives E, López-Aumatell R, Guitart-Masip M, Cañete T, Blázquez G et al. Two-way avoidance acquisition is negatively related to conditioned freezing and positively associated with startle reactions: a dissection of anxiety and fear in genetically heterogeneous rats. Physiol Behav 2011; 103: 148–156.

    CAS  Article  Google Scholar 

  5. 5

    Río-Álamos C, Oliveras I, Cañete T, Blázquez G, Martínez-Membrives E, Tobeña A et al. Neonatal handling decreases unconditioned anxiety, conditioned fear, and improves two-way avoidance acquisition: a study with the inbred Roman high (RHA-I)- and low-avoidance (RLA-I) rats of both sexes. Front Behav Neurosci 2015; 9: 174.

    Article  Google Scholar 

  6. 6

    Gray JA, McNaughton N . The Neuropsychology of anxiety: An enquiry into the function of the septo-hippocampal system, 2nd ed. Oxford University Press: Oxford, 2000; 444p.

    Google Scholar 

  7. 7

    Aguilar R, Gil L, Fernández-Teruel A, Tobeña A . Genetically-based behavioral traits influence the effects of Shuttle Box avoidance overtraining and extinction upon intertrial responding: a study with the Roman rat strains. Behav Processes 2004; 66: 63–72.

    Article  Google Scholar 

  8. 8

    Escorihuela RM, Tobeña A, Fernández-Teruel A . Environmental enrichment reverses the detrimental action of early inconsistent stimulation and increases the beneficial effects of postnatal handling on shuttlebox learning in adult rats. Behav Brain Res 1994; 61: 169–173.

    CAS  Article  Google Scholar 

  9. 9

    Criswell HE, Breese GR . Similar effects of ethanol and flumazenil on acquisition of a shuttle-box avoidance response during withdrawal from chronic ethanol treatment. Br J Pharmacol 1993; 110: 753–760.

    CAS  Article  Google Scholar 

  10. 10

    Lacerra C, Martineja ID, Bustos SG, Molina VA . Benzodiazepine withdrawal facilitates the subsequent onset of escape failures and anhedonia: influence of different antidepressant drugs. Brain Res 1999; 819: 40–47.

    CAS  Article  Google Scholar 

  11. 11

    Bannerman DM, Rawlins JN, McHugh SB, Deacon RM, Yee BK, Bast T et al. Regional dissociations within the hippocampus—memory and anxiety. Neurosci Biobehav Rev 2004; 28: 273–283.

    CAS  Article  Google Scholar 

  12. 12

    McNaughton N, Corr PJ . A two-dimensional neuropsychology of defense: fear/anxiety and defensive distance. Neurosci Biobehav Rev 2004; 28: 285–305.

    Article  Google Scholar 

  13. 13

    Ito R, Lee AC . The role of the hippocampus in approach-avoidance conflict decision-making: evidence from rodent and human studies. Behav Brain Res 2016; 313: 345–357.

    Article  Google Scholar 

  14. 14

    Bach DR, Guitart-Masip M, Packard PA, Miró J, Falip M, Fuentemilla L et al. Human hippocampus arbitrates approach-avoidance conflict. Curr Biol 2014; 24: 541–547.

    CAS  Article  Google Scholar 

  15. 15

    LeDoux J . Anxious. Using the brain to understand and treat fear and anxiety. Penguin Books: New York, 2015; 454p.

    Google Scholar 

  16. 16

    Moreno M, Cardona D, Gómez MJ, Sánchez-Santed F, Tobeña A, Fernández-Teruel A et al. Impulsivity characterization in the Roman high- and low-avoidance rat strains: behavioral and neurochemical differences. Neuropsychopharmacology 2010; 35: 1198–1208.

    Article  Google Scholar 

  17. 17

    Giorgi O, Piras G, Corda MG . The psychogenetically selected Roman high- and low-avoidance rat lines: a model to study the individual vulnerability to drug addiction. Neurosci Biobehav Rev 2007; 31: 148–163.

    CAS  Article  Google Scholar 

  18. 18

    Tournier BB, Steimer T, Millet P, Moulin-Sallanon M, Vallet P, Ibañez V et al. Innately low D2 receptor availability is associated with high novelty-seeking and enhanced behavioural sensitization to amphetamine. Int J Neuropsychopharmacol 2013; 16: 1819–1834.

    CAS  Article  Google Scholar 

  19. 19

    Rio-Alamos C, Oliveras I, Piludu MA, Gerbolés C, Cañete T, Blázquez G et al. Neonatal handling enduringly decreases anxiety and stress responses and reduces hippocampus and amygdala volume in a genetic model of differential anxiety: behavioral-volumetric associations in the Roman rat strains. Eur Neuropsychopharmacol 2017; 27: 146–158.

    CAS  Article  Google Scholar 

  20. 20

    Fadok JP, Krabbe S, Markovic M, Courtin J, Ch Xu, Massi L et al. A competitive inhibitory circuit for selection of active and passive fear responses. Nature 2017; 542: 96–100.

    CAS  Article  Google Scholar 

Download references

Acknowledgements

The authors are supported by grants PSI2013-41872-P and 2014SGR-1587. The authors sincerely thank the anonymous reviewers of this paper for their particularly constructive criticisms and comments.

Author information

Affiliations

Authors

Corresponding author

Correspondence to A Fernández-Teruel.

Ethics declarations

Competing interests

The authors declare no conflict of interest.

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Fernández-Teruel, A., Tobeña, A. Do not bury thirty years of avoidance findings. Mol Psychiatry 23, 497–498 (2018). https://doi.org/10.1038/mp.2017.209

Download citation

Further reading

Search

Quick links