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Genome-wide profiling of multiple histone methylations in olfactory cells: further implications for cellular susceptibility to oxidative stress in schizophrenia

Molecular Psychiatry volume 18, pages 740–742 (2013)Cite this article

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Recent studies have implicated epigenetic mechanisms including histone modifications and DNA methylation in various human diseases.1, 2 Histone H3 lysine 4 trimethylation (H3K4me3) and H3 lysine 27 trimethylation (H3K27me3) are hallmarks of gene activation and repression, respectively.3 These two histone methylations are now known to regulate gene transcriptions in the brain, including those during human brain development.3, 4 In addition, a candidate molecular approach identified an H3K4me3 alteration in the glutamate decarboxylase 1 (GAD1) gene in postmortem brains from patients with schizophrenia (SZ).5 Nonetheless, as far as we are aware, genome-wide unbiased studies for multiple histone modifications are not yet available for SZ.

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  1. C Colantuoni

    Present address: 6Present address: Lieber Institute for Brain Development, Baltimore, MD, USA,

Authors and Affiliations

  1. Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA

    S Kano, C Colantuoni, A Wilson, N Cascella & A Sawa

  2. Department of Biostatistics, Johns Hopkins University School of Public Health, Baltimore, MD, USA

    C Colantuoni, F Han & H Ji

  3. Laboratory of Neurogenetics, National Institute on Alcohol Abuse and Alcoholism, Bethesda, MD, USA

    Z Zhou, Q Yuan & D Goldman

  4. Department of Mental Health, Johns Hopkins University School of Public Health, Baltimore, MD, USA

    Y Takayanagi & W Eaton

  5. Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD, USA

    Y Lee & J Rapoport

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  1. S Kano
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Correspondence to A Sawa.

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Kano, S., Colantuoni, C., Han, F. et al. Genome-wide profiling of multiple histone methylations in olfactory cells: further implications for cellular susceptibility to oxidative stress in schizophrenia. Mol Psychiatry 18, 740–742 (2013). https://doi.org/10.1038/mp.2012.120

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