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Elevated S100B levels in schizophrenia are associated with insulin resistance

Molecular Psychiatry volume 15, pages 3–4 (2010)Cite this article

Several studies have shown that circulating S100B protein levels are elevated in schizophrenia.1 This finding has been specifically attributed to glial pathology, as S100B is produced by astro- and oligodendroglial cells and is thought to act as a neurotrophic factor with effects on synaptogenesis, dopaminergic and glutamatergic neutrotransmission.2 However, this study suggests that overweight and insulin resistance may be alternatively responsible.

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Authors and Affiliations

  1. Department of Psychiatry, University of Magdeburg, Magdeburg, Germany

    J Steiner, M Walter, K Schiltz, B Panteli, M Brauner, H-G Bernstein & B Bogerts

  2. Institute of Biotechnology, University of Cambridge, Cambridge, UK

    P Guest, M Herberth & S Bahn

  3. Department of Psychiatry, University of Munich, Munich, Germany

    A M Myint & M J Schwarz

  4. Institute of Forensic Medicine, Medical University of Gdansk, Gdansk, Poland

    T Gos

  5. Max-Planck-Institute for Human Cognitive and Brain Sciences, Leipzig, Germany

    M L Schroeter

  6. Institute of Clinical Chemistry, Pathobiochemistry and Metabolic Medicine, University of Magdeburg, Magdeburg, Germany

    S Westphal

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  1. J Steiner
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  2. M Walter
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  3. P Guest
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  15. B Bogerts
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Correspondence to J Steiner.

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Steiner, J., Walter, M., Guest, P. et al. Elevated S100B levels in schizophrenia are associated with insulin resistance. Mol Psychiatry 15, 3–4 (2010). https://doi.org/10.1038/mp.2009.87

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