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Are some cases of psychosis caused by microbial agents? A review of the evidence

Molecular Psychiatry volume 13, pages 470–479 (2008)Cite this article

Abstract

The infectious theory of psychosis, prominent early in the twentieth century, has recently received renewed scientific support. Evidence has accumulated that schizophrenia and bipolar disorder are complex diseases in which many predisposing genes interact with one or more environmental agents to cause symptoms. The protozoan Toxoplasma gondii and cytomegalovirus are discussed as examples of infectious agents that have been linked to schizophrenia and in which genes and infectious agents interact. Such infections may occur early in life and are thus consistent with neurodevelopmental as well as genetic theories of psychosis. The outstanding questions regarding infectious theories concern timing and causality. Attempts are underway to address the former by examining sera of individuals prior to the onset of illness and to address the latter by using antiinfective medications to treat individuals with psychosis. The identification of infectious agents associated with the etiopathogenesis of schizophrenia might lead to new methods for the diagnosis, treatment and prevention of this disorder.

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References

  1. Noll R . Historical review: autointoxication and focal infection theories of dementia praecox. World J Biol Psychiatry 2004; 5: 66–72.

    Article  PubMed  Google Scholar 

  2. Ireland WW . Review of: on insanity after acute and chronic infectious diseases. J Mental Sci 1904; 50: 772–773.

    Article  Google Scholar 

  3. Scull A . Madhouse: A Tragic Tale of Megalomania and Modern Medicine. Yale University Press: New Haven, 2005.

    Google Scholar 

  4. Noll R . Infectious insanities, surgical solutions: Bayard Taylor Holmes, dementia praecox and laboratory science in early 20th-century America. Part 2. Hist Psychiatry 2006; 17: 299–311.

    Article  PubMed  Google Scholar 

  5. Althaus J . On psychoses after influenza. J Mental Sci 1893; 39: 163–176.

    Article  Google Scholar 

  6. Menninger KA . Reversible schizophrenia: a study of the implications of delirium schizophrenoides and other post-influenzal syndromes. Am J Psychiatry 1922; 1: 573–588.

    Article  Google Scholar 

  7. Kozar Z . Badania nad toksoplazmoza wsrod umyslowo chorych. Bull Inst Mar Trop Med Gdansk 1953; 5: 146–173 (Summary in English: Studies of toxoplasmosis among the mentally sick. Bull Inst Mar Trop Med Gdansk 1953; 5: 142–145.

    CAS  Google Scholar 

  8. Vojtechovska M, Vojtechovsky M, Petru M . Some problems of parasitology in mental patients (in Czechoslovakian). Casopis Lekaru Ceskych 1956; 95: 559–566.

    CAS  PubMed  Google Scholar 

  9. Morozov VM . On the problem of the viral aetiology of schizophrenia. J Neuropath Psychiat, Korsakov 1954; 54: 732–734.

    CAS  Google Scholar 

  10. Rimon R, Halonen P . Herpes simplex virus infection and depressive illness. Dis Nerv Sys 1969; 30: 338–340.

    CAS  Google Scholar 

  11. Crow TJ, Ferrier IN, Johnstone EC, Macmillan JF, Owens DGC, Parry RP et al. Characteristics of patients with schizophrenia or neurological disorder and virus-like agents in cerebrospinal fluid. Lancet 1979; 1: 842–844.

    Article  CAS  PubMed  Google Scholar 

  12. Chacon C, Monro M, Harper I . Viral infection and psychiatric disorders. Acta Psychiat Scand 1975; 51: 101–103.

    Article  CAS  PubMed  Google Scholar 

  13. Torrey EF, Peterson MR . Slow and latent viruses in schizophrenia. Lancet 1973; 2: 22–24.

    Article  CAS  PubMed  Google Scholar 

  14. Torrey EF, Yolken RH, Winfrey CJ . Cytomegalovirus antibody in cerebrospinal fluid of schizophrenic patients detected by enzyme immunoassay. Science 1982; 216: 892–894.

    Article  CAS  PubMed  Google Scholar 

  15. Morozov PV (ed). Research on the Viral Hypothesis of Mental Disorders. Karger: Basel, 1983.

    Google Scholar 

  16. Torrey EF . Functional psychoses and viral encephalitis. Integr Psychiatry 1986; 4: 224–236.

    Google Scholar 

  17. Little JT, Sunderland T . Psychosis secondary to encephalitis and encephalopathies. Semin Clin Neuropsychiatry 1998; 3: 4–11.

    CAS  PubMed  Google Scholar 

  18. Caroff SN, Mann SC, Gliatto MF, Sullivan KA, Campbell EC . Psychiatric manifestations of acute viral encephalitis. Psych Annals 2001; 31: 193–204.

    Article  Google Scholar 

  19. Torrey EF, Miller J, Rawlings R, Yolken RH . Seasonality of births in schizophrenia and bipolar disorder: a review of the literature. Schizophr Res 1997; 28: 1–38.

    Article  CAS  PubMed  Google Scholar 

  20. Eaton WW, Mortensen PB, Frydenberg M . Obstetric factors, urbanization and psychosis. Schizophr Res 2000; 43: 117–123.

    Article  CAS  PubMed  Google Scholar 

  21. Pedersen CB, Mortensen PB . Evidence of a dose–response relationship between urbanicity during upbringing and schizophrenia risk. Arch Gen Psychiatry 2001; 58: 1039–1046.

    Article  CAS  PubMed  Google Scholar 

  22. Mortensen PB, Pedersen CB, Westergaard T, Wohlfahrt J, Ewald H, Mors O et al. Effects of family history and place and season of birth on the risk of schizophrenia. N Engl J Med 1999; 340: 603–608.

    Article  CAS  PubMed  Google Scholar 

  23. Harrison G, Fouskakis D, Rasmussen F, Tynelius P, Sipos A, Gunnell D . Association between psychotic disorder and urban place of birth is not mediated by obstetric complications or childhood socio-economic position: a cohort study. Psychol Med 2003; 33: 723–731.

    Article  CAS  PubMed  Google Scholar 

  24. Brown AS, Cohen P, Greenwald S, Susser E . Nonaffective psychosis after prenatal exposure to rubella. Am J Psychiatry 2000; 157: 438–443.

    Article  CAS  PubMed  Google Scholar 

  25. Brown AS, Begg MD, Gravenstein S, Schaefer CA, Wyatt RJ, Bresnahan MA et al. Serologic evidence for prenatal influenza in the etiology of schizophrenia. Arch Gen Psychiatry 2004; 61: 774–780.

    Article  PubMed  Google Scholar 

  26. Buka SL, Tsuang MT, Torrey EF, Klebanoff MA, Bernstein D, Yolken RH . Maternal infections and subsequent psychosis among offspring. Arch Gen Psychiatry 2001; 58: 1032–1037.

    Article  CAS  PubMed  Google Scholar 

  27. Brown AS, Schaefer CA, Quesenberry Jr CP, Liu L, Babulas VP, Susser ES . Maternal exposure to toxoplasmosis and risk of schizophrenia in adult offspring. Am J Psychiatry 2005; 162: 767–773.

    Article  PubMed  Google Scholar 

  28. Mortensen PB, Nørgaard-Pedersen B, Waltoft BL, Sørensen T, Hougaard D, Torrey EF et al. Toxoplasma gondii as a risk factor for early-onset schizophrenia: analysis of filter paper blood samples obtained at birth. Biol Psychiatry 2007; 61: 688–693.

    Article  PubMed  Google Scholar 

  29. Abraho AL, Focaccia R, Gattaz WF . Childhood meningitis increases the risk for adult schizophrenia. World J Biol Psychiatry 2005; 6 (Suppl 2): 44–48.

    Article  Google Scholar 

  30. Gilbody S, Lewis S, Lightfoot T . Methylenetetrahydrofolate reductase (MTHFR) genetic polymorphisms and psychiatric disorders: a HuGE review. Am J Epidemiol 2007; 165: 1–13.

    Article  PubMed  Google Scholar 

  31. Haldane JBS . The rate of mutation of human genes. Hereditas 1948; 35 (Suppl): 267–273.

    Google Scholar 

  32. Burgner D, Jamieson SE, Blackwell JM . Genetic susceptibility to infectious diseases: big is beautiful, but will bigger be even better. Lancet Infect Dis 2006; 6: 653–663.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Jones JL, Kruszon-Moran D, Wilson M, McQuillan G, Navin T, McAuley JB . Toxoplasma gondii infection in the United States: seroprevalence and risk factors. Am J Epidemiol 2001; 154: 357–365.

    Article  CAS  PubMed  Google Scholar 

  34. Jackson MH, Hutchison WM . The prevalence and source of Toxoplasma infection in the environment. Adv Parasitol 1989; 28: 55–105.

    Article  CAS  PubMed  Google Scholar 

  35. Beverley JKA, Fleck DG, Kwantes W, Ludlam GB . Age-sex distribution of various diseases with particular reference to toxoplasmic lymphadenopathy. J Hyg (Camb) 1976; 76: 215–228.

    Article  CAS  Google Scholar 

  36. Bannister B . Toxoplasmosis 1976–80: review of laboratory reports to the Communicable Disease Surveillance Centre. J Infect 1982; 5: 301–306.

    Article  Google Scholar 

  37. Tizard IR, Fish NA, Quinn JP . Some observations on the epidemiology of toxoplasmosis in Canada. J Hyg (Camb) 1976; 77: 11–21.

    Article  CAS  Google Scholar 

  38. Ades AE, Parker S, Gilbert R, Tookey PA, Berry T, Hjelm M et al. Maternal prevalence of toxoplasma antibody based on anonymous neonatal serosurvey: a geographical analysis. Epidemiol Infect 1993; 110: 127–133.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Lutjen S, Soltek S, Virna S, Deckert M, Schluter D . Related articles, organ- and disease-stage-specific regulation of Toxoplasma gondii-specific CD8-T-cell responses by CD4T cells. Infect Immun 2006; 74: 5790–5801.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  40. Tato CM, Mason N, Artis D, Shapira S, Caamano JC, Bream JH et al. Opposing roles of NF-kappaB family members in the regulation of NK cell proliferation and production of IFN-gamma. Int Immunol 2006; 18: 505–513.

    Article  CAS  PubMed  Google Scholar 

  41. Lang C, Algner M, Beinert N, Gross U, Luder CG . Diverse mechanisms employed by Toxoplasma gondii to inhibit IFN-gamma-induced major histocompatibility complex class II gene expression. Microbes Infect 2006; 8: 1994–2005.

    Article  CAS  PubMed  Google Scholar 

  42. Schluter D, Kwok LY, Lutjen S, Soltek S, Hoffmann S, Korner H et al. Both lymphotoxin-alpha and TNF are crucial for control of Toxoplasma gondii in the central nervous system. J Immunol 2003; 170: 6172–6182.

    Article  PubMed  Google Scholar 

  43. Kasper L, Courret N, Darche S, Luangsay S, Mennechet F, Minns L et al. Toxoplasma gondii and mucosal immunity. Int J Parasitol 2004; 34: 401–409.

    Article  CAS  PubMed  Google Scholar 

  44. Yarovinsky F, Kanzler H, Hieny S, Coffman RL, Sher A . Toll-like receptor recognition regulates immunodominance in an antimicrobial CD4+ T cell response. Immunity 2006; 25: 655–664.

    Article  CAS  PubMed  Google Scholar 

  45. Khan IA, Thomas SY, Moretto MM, Lee FS, Islam SA, Combe C et al. CCR5 is essential for NK cell trafficking and host survival following Toxoplasma gondii infection. PLoS Pathog 2006; 2: e49.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  46. Buzoni-Gatel D, Werts C . Toxoplasma gondii and subversion of the immune system. Trends Parasitol 2006; 22: 448–452.

    Article  CAS  PubMed  Google Scholar 

  47. de Moura L, Bahia-Oliveira LMG, Wada MY, Jones JL, Tuboi SH, Carmo EH et al. Waterborne toxoplasmosis, Brazil, from field to gene. Emerg Infect Dis 2006; 12: 326–329.

    Article  PubMed  PubMed Central  Google Scholar 

  48. Kramer W . Frontiers of neurological diagnosis in acquired toxoplasmosis. Psychiatr Neurol Neurochir 1966; 69: 43–64.

    CAS  PubMed  Google Scholar 

  49. Estran C, Brenier-Pinchart MP, Pelletier L, Cesbron-Delauw MF, Pelloux H . Toxoplasma gondii in human astrocytes in vitro: interleukin (IL)-12 and IL-10 do not influence cystogenesis. J Parasitol 2006; 92: 1108–1110.

    Article  CAS  PubMed  Google Scholar 

  50. Torrey EF, Bartko JJ, Lun Z-R, Yolken RH . Antibodies to Toxoplasma gondii in patients with schizophrenia: a meta-analysis. Schizophr Bull 2007; 33: 729–736.

    Article  PubMed  Google Scholar 

  51. Niebuhr DW, Millikan AM, Cowan DN, Yolken R, Li Y, Weber NS . Selected infectious agents and risk of schizophrenia among U.S. Military personnel. Am J Psychiatry 2008; 165: 99–106.

    Article  PubMed  Google Scholar 

  52. Saeij JP, Coller S, Boyle JP, Jerome ME, White MW, Boothroyd JC . Toxoplasma co-opts host gene expression by injection of a polymorphic kinase homologue. Nature 2007; 445: 324–327.

    Article  CAS  PubMed  Google Scholar 

  53. Taylor S, Barragan A, Su C, Fux B, Fentress SJ, Tang K et al. A secreted serine-threonine kinase determines virulence in the eukaryotic pathogen Toxoplasma gondii. Science 2006; 314: 1776–1780.

    Article  CAS  PubMed  Google Scholar 

  54. Webster JP, Lamberton PH, Donnelly CA, Torrey EF . Parasites as causative agents of human affective disorders? The impact of anti-psychotic, mood-stablizer and anti-parasite medication on Toxoplasma gondii's ability to alter host behaviour. Proc Biol Sci 2006; 273: 1023–1030.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  55. Yereli K, Balcioğlu IC, Özbilgin A . Is Toxoplasma gondii a potential risk for traffic accidents in Turkey? Forensic Sci Int 2006; 163: 34–37.

    Article  PubMed  Google Scholar 

  56. Flegr J, Havlicek J, Kodym P, Maly M, Smalhel Z . Increased risk of traffic accidents in subjects with latent toxoplasmosis: a retrospective case control study. BMC Infect Dis 2002; 2: 11–16.

    Article  PubMed  PubMed Central  Google Scholar 

  57. Mohammed AK, Magnusson O, Maehlen J, Fonnum F, Norrby E, Schultzberg M et al. Behavioural deficits and serotonin depletion in adult rats after transient infant nasal viral infection. Neuroscience 1990; 35: 355–363.

    Article  CAS  PubMed  Google Scholar 

  58. Carruthers VB, Suzuki Y . Effects of Toxoplasma gondii infection on the brain. Schizophr Bull 2007; 33: 745–751.

    Article  PubMed  PubMed Central  Google Scholar 

  59. Radke JR, Behnke MS, Mackey AJ, Radke JB, Roos DS, White MW . The transcriptome of Toxoplasma gondii. BMC Biol 2005; 3: 26.

    Article  PubMed  PubMed Central  CAS  Google Scholar 

  60. Czub S, Koutsilieri E, Sopper S, Czub M, Stahl-Hennig C, Müller JG et al. Enhancement of central nervous system pathology in early simian immunodeficiency virus infection by dopaminergic drugs. Acta Neuropathol 2001; 101: 85–91.

    CAS  PubMed  Google Scholar 

  61. Ashdown H, Dumont Y, Ng M, Poole S, Boksa P, Luheshi GN . The role of cytokines in mediating effects of prenatal infection on the fetus: implications for schizophrenia. Mol Psychiatry 2006; 11: 47–55.

    Article  CAS  PubMed  Google Scholar 

  62. Hanshaw JB . Congenital cytomegalovirus infection: a fifteen year perspective. J Infect Dis 1971; 123: 555–561.

    Article  CAS  PubMed  Google Scholar 

  63. Hurme M, Helminen M . Resistance to human cytomegalovirus infection may be influenced by genetic polymorphisms of the tumour necrosis factor-alpha and interleukin-1 receptor antagonist genes. Scand J Infect Dis 1998; 30: 447–449.

    Article  CAS  PubMed  Google Scholar 

  64. Schwab SG, Mondabon S, Knapp M, Albus M, Hallmayer J, Borrmann-Hassenbach M et al. Association of tumor necrosis factor alpha gene-G308A polymorphism with schizophrenia. Schizophr Res 2003; 65: 19–25.

    Article  PubMed  Google Scholar 

  65. Boin F, Zanardini R, Pioli R, Altamira CA, Maes M, Gennarelli M . Association between -G308A tumor necrosis factor alpha gene polymorphism and schizophrenia. Mol Psychiatry 2001; 6: 79–82.

    Article  CAS  PubMed  Google Scholar 

  66. Riedel M, Krönig H, Schwarz MJ . No association between the G308A polymorphism of the tumor necrosis factor-alpha gene and schizophrenia. Eur Arch Psychiatry Clin Neurosci 2002; 252: 232–234.

    Article  PubMed  Google Scholar 

  67. Hurme M, Haanpaa M, Nurmikko T, Wang XY, Virta M, Pessi T et al. IL-10 gene polymorphism and herpesvirus infections. J Med Virol 2003; 70 (Suppl 1): S48–S50.

    Article  CAS  PubMed  Google Scholar 

  68. Chiavetto LB, Boin F, Zanardini R, Popoli M, Michelato A, Bignotti S et al. Association between promoter polymorphic haplotypes of interleukin-10 gene and schizophrenia. Biol Psychiatry 2002; 51: 480–484.

    Article  CAS  Google Scholar 

  69. Hanshaw JB, Scheiner AP, Moxley AW, Gaev L, Abel V, Scheiner B . School failure and deafness after ‘silent’ congenital cytomegalovirus infection. N Engl J Med 1976; 295: 468–470.

    Article  CAS  PubMed  Google Scholar 

  70. Boppana SB, Rivera LB, Fowler KB, Mach M, Britt WJ . Intrauterine transmission of cytomegalovirus to infants of women with preconceptional immunity. N Engl J Med 2001; 344: 1366–1371.

    Article  CAS  PubMed  Google Scholar 

  71. Duchowny M, Caplan L, Siber G . Cytomegalovirus infection of the adult nervous system. Ann Neurol 1979; 5: 458–461.

    Article  CAS  PubMed  Google Scholar 

  72. Dickerson F, Kirkpatrick B, Boronow J, Stallings C, Origoni A, Yolken R . Deficit schizophrenia: association with serum antibodies to cytomegalovirus. Schizophr Bull 2006; 32: 396–400.

    Article  PubMed  PubMed Central  Google Scholar 

  73. Hoff AL, DeLisi LE, Yolken RH . Relationship of viral infection to progressive MRI and neuropsychological change in a 10 year follow-up study of first episode schizophrenia (abstract). Neuropsychopharmacology 2004; 29 (Suppl 1): S164.

    Google Scholar 

  74. Hanshaw JB . Cytomegalovirus. In: Remington JS, Klein JO (eds). Infectious Diseases of the Fetus and Newborn Infant. Saunders: Philadelphia, 1976, p 127.

    Google Scholar 

  75. Lokensgard JR, Cheeran MC-J, Hu S, Gekker G, Peterson PK . Glial cell responses to herpesvirus infections: role in defense and immunopathogenesis. J Infect Dis 2002; 186 (Suppl 2): S171–S179.

    Article  PubMed  Google Scholar 

  76. Rothschild DM, O'Grady M, Wecker L . Neonatal cytomegalovirus exposure decreases prepulse inhibition in adult rats: implications for schizophrenia. J Neurosci Res 1999; 57: 429–434.

    Article  CAS  PubMed  Google Scholar 

  77. Yolken RH, Torrey EF . Viruses, schizophrenia, and bipolar disorder. Clin Microbiol Rev 1995; 8: 131–145.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  78. Torrey EF, Leweke MF, Schwarz MJ, Mueller N, Bachmann S, Schroeder J et al. Cytomegalovirus and schizophrenia. CNS Drugs 2006; 20: 879–885.

    Article  PubMed  Google Scholar 

  79. Leweke FM, Gerth CW, Koethe D, Klosterkotter J, Ruslanova I, Krivogorsky B et al. Antibodies to infectious agents in individuals with recent onset schizophrenia. Eur Arch Psychiatr Clin Neurosci 2004; 254: 4–8.

    Article  Google Scholar 

  80. Moises HW, Rüger R, Reynolds GP, Fleckenstein B . Human cytomegalovirus DNA in the temporal cortex of a schizophrenic patient. Eur Arch Psychiatr Neurol Sci 1988; 238: 110–113.

    CAS  Google Scholar 

  81. Jones-Brando L, Torrey EF, Yolken RH . Drugs used in the treatment of schizophrenia and bipolar disorder inhibit the replication of Toxoplasma gondii. Schizophr Res 2003; 62: 237–244.

    Article  PubMed  Google Scholar 

  82. Dickerson FB, Boronow JJ, Stallings CR, Origoni AE, Yolken RH . Reduction of symptoms by valacyclovir in cytomegalovirus-seropositive individuals with schizophrenia. Am J Psychiatry 2003; 160: 2234–2236.

    Article  PubMed  Google Scholar 

  83. Mueller N, Riedel M, Scheppach C, Brandstatter B, Sokullu S, Krampe K et al. Beneficial antipsychotic effects of celecoxib add-on therapy compared to risperidone alone in schizophrenia. Am J Psychiatry 2002; 159: 1029–1034.

    Article  Google Scholar 

  84. Martelius TJ, Wolff H, Bruggeman CA, Hockerstedt KA, Lautenschlager IT . Induction of cyclo-oxygenase-2 by acute liver allograft rejection and cytomegalovirus infection in the rat. Transpl Int 2002; 15: 610–614.

    Article  CAS  PubMed  Google Scholar 

  85. Zhu H, Cong JP, Yu D, Bresnahan WA, Shenk TE . Inhibition of cyclooxygenase 2 blocks human cytomegalovirus replication. Proc Natl Acad Sci USA 2002; 99: 3932–3937.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  86. Dickerson MC, Johnston J, Delea TE, White A, Andrews E . The causal role for genital ulcer disease as a risk factor for transmission of human immunodeficiency virus. An application of the Bradford Hill criteria. Sex Transm Dis 1996; 23: 429–440.

    Article  CAS  PubMed  Google Scholar 

  87. Yolken RH, Torrey EF . Infectious agents and gene-environmental interactions in the etiopathogenesis of schizophrenia. Clin Neurosci Res 2006; 6: 97–109.

    Article  CAS  Google Scholar 

  88. Jones-Brando L, D'Angelo J, Posner GH, Yolken R . In vitro inhibition of Toxoplasma gondii by four new derivatives of artemisinin. Antimicrob Agents Chemother 2006; 50: 4206–4208.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Authors and Affiliations

  1. Department of Pediatrics, The Stanley Laboratory of Developmental Neurovirology, Johns Hopkins University Medical Center, Baltimore, MD, USA

    R H Yolken

  2. The Stanley Medical Research Institute, Chevy Chase, MD, USA

    E F Torrey

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Yolken, R., Torrey, E. Are some cases of psychosis caused by microbial agents? A review of the evidence. Mol Psychiatry 13, 470–479 (2008). https://doi.org/10.1038/mp.2008.5

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Keywords

  • cytomegalovirus
  • toxoplasmosis
  • infectious
  • schizophrenia
  • genetic
  • environmental

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