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Altered prepulse inhibition in mice with dendrite abnormalities of hippocampal neurons

Molecular Psychiatry volume 13, pages 656–658 (2008)Cite this article

Deciphering sensory gating mechanisms may give clues to some of the neurophysiological deficits present in mental disorders. Here, we report an alteration of prepulse inhibition (PPI) and dendrite abnormalities of the hippocampus in mice with targeted disruption of the collapsin response mediator protein-3 (CRMP3) gene.

Sensorimotor gating deficits, by allowing irrelevant thoughts and sensory stimuli into conscious awareness, may contribute to the etiopathogeny of hallucinations, delusions and cognitive disintegration. Accordingly, measures of sensory gating are used to elucidate neurophysiological abnormalities in schizophrenia.1 PPI, the phenomenon in which a low-intensity prepulse stimulus attenuates the response to a succeeding startle-eliciting pulse stimulus, is considered an index of sensory gating function, and the hippocampus plays an important role in its modulation.2 Patients with schizophrenia display abnormal PPI1 and several cytoarchitectural abnormalities of the hippocampus,3 including decreases in dendritic length, in apical dendritic arborization and in microtubule-associated protein-2 (MAP2) staining.4 Although PPI is altered in other diseases, it has been proposed as a tool to identify candidate genes for schizophrenia and to develop animal models.5 Indeed, several genes implicated in neurite development and in PPI regulation—for example, neuregulin-1, reelin, N-CAM180, DISC1—are also potential susceptibility genes for the disease.6

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Authors and Affiliations

  1. INSERM U842, Université Lyon-1, Lyon, France

    T T Quach & J Honnorat

  2. Department of Psychology, The Ohio State University, Columbus, OH, USA

    E R Glasper & A C Devries

  3. Biomolecular Science Center, Burnett College of Biomedical Sciences, University of Central Florida, Orlando, FL, USA

    P E Kolattukudy

  4. Department of Psychiatry, The Ohio State University, Columbus, OH, USA

    A M Duchemin

Authors
  1. T T Quach
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  2. E R Glasper
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  3. A C Devries
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  4. J Honnorat
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  5. P E Kolattukudy
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  6. A M Duchemin
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Correspondence to A M Duchemin.

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Quach, T., Glasper, E., Devries, A. et al. Altered prepulse inhibition in mice with dendrite abnormalities of hippocampal neurons. Mol Psychiatry 13, 656–658 (2008). https://doi.org/10.1038/mp.2008.27

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