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Death defying

Apoptosis and cancer

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  1. Kerr, J. F., Wyllie, A. H. & Currie, A. R. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br. J. Cancer 26, 239–257 (1972)

    CAS  Article  Google Scholar 

  2. Vaux, D. L., Cory, S. & Adams, J. M. Bcl-2 gene promotes haemopoietic cell survival and cooperates with c-myc to immortalize pre-B cells. Nature 335, 440–442 (1988)

    CAS  Article  Google Scholar 


  1. Reed, J. C., Cuddy, M., Slabiak, T., Croce, C. M. & Nowell, P. C. Oncogenic potential of bcl-2 demonstrated by gene transfer. Nature 336, 259–261 (1988)

    CAS  Article  Google Scholar 

  2. McDonnell, T. M. et al. bcl-2–immunoglobulin transgenic mice demonstrate extended B cell survival and follicular lymphoproliferation. Cell 57, 79–88 (1989)

    CAS  Article  Google Scholar 

  3. Williams, G. T., Smith, C. A., Spooncer, E., Dexter, T. M. & Taylor, D. R. Haemopoietic colony stimulating factors promote cell survival by suppressing apoptosis. Nature 343, 76–79 (1990)

    CAS  Article  Google Scholar 

  4. Askew, D. S., Ashmun, R. A., Simmons, B. C. & Cleveland, J. L. Constitutive c-myc expression in an IL-3-dependent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis. Oncogene 6, 1915–1922 (1991)

    CAS  PubMed  Google Scholar 

  5. Evan, G. I. et al. Induction of apoptosis in fibroblasts by c-myc protein. Cell 69, 119–128 (1992)

    CAS  Article  Google Scholar 

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McCarthy, N. Death defying. Nat Rev Cancer 6 (Suppl 1), S14–S15 (2006).

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