Lymphotoxin and IL-22
Jeff Browning provides an insightful look at recent findings implicating a role for lymphotoxin-b-receptor signaling in interleukin-22 production by innate lymphoid cells. See page 228
New insights into oral tolerance
Oliver Pabst and Allan Mowat discuss new data and provide a stepwise model for understanding the mechanisms underlying oral tolerance to food proteins. See page 232
IL-17 in the pathogenesis of IBD
Takanori Kanai and colleagues describe recent findings regarding the role of interleukin-17A in the pathogenesis of inflammatory bowel disease. See page 240
HIV shedding during ART
Prameet Sheth and colleagues demonstrate that cytomegalovirus reactivation is not the culprit in intermittent shedding of HIV in the semen of patients on antiretroviral therapy. They provide data correlating viral shedding with the presence of activated T cells. See page 248
Protecting neutrophils with IL-6
Oliver Dienz and colleagues show that interleukin-6 is necessary for the resolution of influenza infection by virtue of its ability to protect neutrophils from virus-induced cell death. See page 258
Oral desensitization with omalizamab coadministration
Denis Bedoret and colleagues describe a novel and effective method for orally desensitizing children with significant cow’s milk allergy by coadministering omalizamab, a monoclonal anti–immunoglobulin E monoclonal antibody. See page 267
Mucosal inflammation and HIV risk
Julie Lajoie and co-workers found that HIV-1-exposed but seronegative commercial sex workers from Nairobi expressed a distinct pattern of cytokines and chemokines in their genital mucosa. The pattern indicates less inflammation and T-cell trafficking to local mucosal tissues, consistent with the immune quiescence model of protection. See page 277
NLRC4 in the intestine
Frederic Carvalho and colleagues show that the NLRC4 inflammasome is important for protecting the intestine in dextran sulfate sodium–induced colitis and Salmonella infection but has little role in the activation of the innate immune system following experimental flagellin administration. See page 288
IL-4R and pulmonary cryptococcosis
Uwe Müller and co-workers demonstrate an essential role for interleukin-4R on T helper (Th) cells in susceptibility to Th2-dependent bronchopulmonary Cryptococcus neoformans infection. See page 299
Novel adenovirus vaccine expressing reovirus σ1
Eric Weaver and colleagues report on a novel adenovirus vaccine that displays the 1 protein from reovirus to target epithelial cells. See page 311
Th17 responses to N. gonorrhoeae
Yingru Liu and co-workers examine the ability of Neisseria gonorrhoeae to drive T helper type 17 cell differentiation via the induction of transforming growth factor-b production. See page 320
iTregs and airway hyperresponsiveness
Deborah Strickland and colleagues show that the high susceptibility of the BN rat strain to aeroallergen-induced persistent airway hyperresponsiveness is associated with deficiencies in inducible T-regulatory cell function and trafficking. See page 332
TSLP and the atopic march
Hongwei Han and co-workers established a role for skin-derived thymic stromal lymphopoietin (TSLP) in the exacerbation of experimental asthma in a novel mouse model of the “atopic march.” See page 342
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In this Issue. Mucosal Immunol 5, 227 (2012). https://doi.org/10.1038/mi.2012.25
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DOI: https://doi.org/10.1038/mi.2012.25