IL-17 and inflammatory bowel disease

In News & Highlights, Ivan Fuss discusses studies addressing the role of interleukin-17 (IL-17) and interferon-γ in inflammatory bowel disease, including recent clinical trials using anti-IL-17A-neutralizing antibodies. See page 366

Facets of TL1A

Focusing on two articles in the March 2011 issue of Mucosal Immunology, Hailing Hsu and Joanne Viney examine recent insights into the functions of TL1A (TNFSF15) and its receptor DR3 in driving inflammation in the gut and lung. See page 368

Immunity to Salmonella

Amanda Griffin and Stephen McSorley review progress in elucidating the induction and evasion of immunity to Salmonella infections. See page 371

Organ cultures for HIV

Peter Southern and colleagues discuss recent progress and limitations in the use of human organ culture systems to study early phases of HIV infection. See page 383

IL-13 and conjunctival goblet cells

Cintia De Paiva and colleagues demonstrated that interleukin-13 produced by natural killer T cells induces the development of goblet cells in the conjunctiva of the eye, a function that is lost under conditions of desiccating stress. See page 397

Gingival defense

Lei Yin and Whasun Chung showed that epigenetic modifications affect the production of human β-defensin 2 and CC chemokine ligand 20 from gingival epithelial cells in response to oral bacteria. See page 409

Stromal cell cytokines in inflammatory bowel disease

Kayci Huff and colleagues investigated the effects on CD4+ T-cell differentiation of cytokines from intestinal stromal cells from individuals with and without inflammatory bowel disease. See page 420

CD4+ T cells and bladder inflammation

Wujiang Liu and colleagues described the ability of activated CD4+ T cells to cause bladder inflammation in mice expressing ovalbumin in urothelial cells. See page 428

Bile retinoids imprint CD103+ dendritic cells

Elin Jaensson-Gyllenbäck and colleagues determined that bile retinoids are sufficient to imprint CD103+ dendritic cells for the induction of homing receptors on gut-tropic T cells. See page 438

IL-17 and oral candidiasis

Heather Conti and co-workers identified a novel role for interleukin-17 in driving candidacidal protein production in the saliva, which is lacking in patients who lack T helper type 17 cells because of mutations in the signal transducer and activator of transcription 3 transcription factor. See page 448

Transcutaneous immunization for otitis media

Laura Novotny and colleagues demonstrated that transcutaneous immunization is an effective mechanism for control of otitis media in an animal model of Haemophilus influenzae infection. See page 456

Regulation of pIgR by NF-κB

Maria Bruno and co-workers found that expression of interleukin-8 and that of the polymeric immunoglobulin receptor by Toll-like receptor–activated epithelial cells are differentially dependent on RelA and RelB signaling. See page 468