Mutational landscape in children with myelodysplastic syndromes is distinct from adults: specific somatic drivers and novel germline variants

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Acknowledgements

We are thankful to Christina Jäger, Sophia Hollander, Sandra Zolles, Alexandra Fischer, Wilfried Truckenmüller, Peter Nöllke and Anne Strauss (Freiburg) for excellent laboratory assistance and for the data management, and to Pontus Lundberg (Basel) for the data analysis. The funding was obtained from Deutsche Krebshilfe (Max Eder grant #109005) to MWW and the MDS consortium grant (#110293) to CF and CMN, German Federal Ministry of Education and Research (DKTK German cancer consortium, molecular diagnostics of pediatric malignancies) to CMN, CF and MWW. Swiss Cancer League (KLS-2950-02-2012) and Else Kröner-Fresenius Foundation (2011_A01) to RCS.

Author contributions

VP, MWW, CF, CMN contributed to study design and manuscript writing. BS, CF, CMN, MWW, TR, GG, MN, AY, SS, IB, GR, DL were involved in the care of patients, testing procedures and sample acquisition. MWW, VP, AK, JW, RCS, RN carried out the research. All authors read and approved the manuscript.

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Correspondence to M W Wlodarski.

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The authors declare no conflict of interest.

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Pastor, V., Hirabayashi, S., Karow, A. et al. Mutational landscape in children with myelodysplastic syndromes is distinct from adults: specific somatic drivers and novel germline variants. Leukemia 31, 759–762 (2017). https://doi.org/10.1038/leu.2016.342

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