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This work was supported by Grant-in-Aids from the Ministry of Health, Labor and Welfare of Japan and KAKENHI (23249052, 22134006, 21790907, 15km0305018h0101, 16H05338, 26115009, 26890016 and 15H05668) (Kyoto; SO, HM, MS and KY), project for development of innovative research on cancer therapies (p-direct) (Kyoto, SO), The Japan Society for the Promotion of Science (JSPS) through the ‘Funding Program for World-Leading Innovative R&D on Science and Technology’, initiated by the Council for Science and Technology Policy (CSTP) (Kyoto, SO) and NHRI-EX100-10003NI Taiwan (Taipei LYS).
TM, YN, HidM, MS, SO and KY performed study design and interpretation of the data. TM, YN, MS, YusS, AK, TY, ASO, KK and RK performed molecular experiments and data analysis. YuiS, KC, HT and SaM performed bioinformatics. KI, ShM, HirM, TsN, RK, HK, HPK, LYS, ToN, CH, WK and TH collected samples and clinical data, contributed to the interpretation of the data and critically reviewed the draft.
TH, CH and WK declare equity ownership of MLL Munich Leukemia Laboratory GmbH.
Supplementary Information accompanies this paper on the Leukemia website
About this article
International Journal of Molecular Sciences (2019)
Journal of Internal Medicine (2019)
Nature Medicine (2018)