Syk kinase and Shp2 phosphatase inhibition cooperate to reduce FLT3-ITD-induced STAT5 activation and proliferation of acute myeloid leukemia

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This work was supported by the Riley Children’s Foundation and U.S. National Institutes of Health (F31 CA183342 to BMR; RO1 CA134777 to RJC, RK; RO1 HL077177, HL081111 and CA173852 to RK; RO1 CA96202 to Z-YZ; and the Indiana Clinical and Translational Sciences Institute, funded in part by UL1 TR000006 to JDB). We appreciate the technical assistance from Dr Karen Pollok and Tony Sinn in the Indiana University In Vivo Therapeutics Core and from Susan Rice in the Flow Cytometry Resource Facility (supported by P30 CA082709). We gratefully acknowledge the administrative assistance of Marilyn L Wales and Tracy Winkle.

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Correspondence to R J Chan.

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