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BH3 profiling identifies heterogeneous dependency on Bcl-2 family members in multiple myeloma and predicts sensitivity to BH3 mimetics

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Acknowledgements

We gratefully acknowledge support from NIH grants R01CA129974. CT was supported by the Fondation Française pour la Recherche contre le Myélome et les Gammapathies monoclonales (F.F.R.M.G.).

Author contributions

AL and CT designed the research and wrote the manuscript. CT performed the experiments. CT, AL, JR, TNC analyzed the data. PR, KA, MA, SLG and PM provided myeloma cells. All the authors critically reviewed the manuscript.

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Correspondence to A Letai.

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Competing interests

AL has been a paid advisor to AbbVie. AL’s laboratory has received sponsorship for research with AbbVie.

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Supplementary Information accompanies this paper on the Leukemia website

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Touzeau, C., Ryan, J., Guerriero, J. et al. BH3 profiling identifies heterogeneous dependency on Bcl-2 family members in multiple myeloma and predicts sensitivity to BH3 mimetics. Leukemia 30, 761–764 (2016). https://doi.org/10.1038/leu.2015.184

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