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Prognostic gene mutations and distinct gene- and microRNA-expression signatures in acute myeloid leukemia with a sole trisomy 8

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The Cancer and Leukemia Group B (CALGB) institutions, principal investigators and cytogeneticists participating in this study are provided in the Supplementary Information. The research was supported in part by National Cancer Institute, Bethesda, MD grants CA101140, CA140158, CA114725, CA129657, CA16058, CA77658, The Coleman Leukemia Research Foundation, the Deutsche Krebshilfe—Dr Mildred Scheel Foundation (to HB) and the Research Committee of the University Freiburg, Germany (to HB), the Pelotonia Fellowship Program (to A-KE), and the Conquer Cancer Foundation (to JHM). The research for CALGB 8461, 20202 and 9665 (Alliance) was supported, in part, by grants from the National Cancer Institute (CA31946) to the Alliance for Clinical Trials in Oncology (Monica M Bertagnolli, Chair) and to the Alliance Statistics and Data Center (Daniel J Sargent, CA33601). The content of this manuscript is solely the responsibility of the authors and does not necessarily represent the official views of the National Cancer Institute. We thank Donna Bucci and the CALGB Leukemia Tissue Bank at The Ohio State University Comprehensive Cancer Center, Columbus, OH, for sample processing and storage services, Colin G Edwards, PhD, Lisa J Sterling and Christine Finks for data management, and Dean Margeson and Kelsi B Holland for assistance in the statistical analyses. Moreover, we thank Stephan M Tanner, PhD and Albert de la Chapelle, MD, PhD for scientific discussions.

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Correspondence to G Marcucci or C D Bloomfield.

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HB, K Maharry, K Mrózek, SV, MDR, GM and CDB contributed to the design and analysis of this study and the writing of this manuscript, and all authors agreed on the final version; HB, A-KE, KHM, SS, SPW, JHM, Y-ZW and PP carried out laboratory-based research; K Maharry, SV, MDR, JK and DN performed statistical analyses; and BLP, THC, MW, JEK, AJC, MRB, MAC, RMS, GM and CDB were involved directly or indirectly in the care of patients and/or sample procurement.

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Becker, H., Maharry, K., Mrózek, K. et al. Prognostic gene mutations and distinct gene- and microRNA-expression signatures in acute myeloid leukemia with a sole trisomy 8. Leukemia 28, 1754–1758 (2014).

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