This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Dohner H, Stilgenbauer S, Benner A, Leupolt E, Krober A, Bullinger L et al. Genomic aberrations and survival in chronic lymphocytic leukemia. N Engl J Med 2000; 343: 1910–1916.
Athanasiadou A, Stamatopoulos K, Tsompanakou A, Gaitatzi M, Kalogiannidis P, Anagnostopoulos A et al. Clinical, immunophenotypic, and molecular profiling of trisomy 12 in chronic lymphocytic leukemia and comparison with other karyotypic subgroups defined by cytogenetic analysis. Cancer Genet Cytogenet 2006; 168: 109–119.
Juliusson G, Merup M . Cytogenetics in chronic lymphocytic leukemia. Semin Oncol 1998; 25: 19–26.
Schwaenen C, Nessling M, Wessendorf S, Salvi T, Wrobel G, Radlwimmer B et al. Automated array-based genomic profiling in chronic lymphocytic leukemia: development of a clinical tool and discovery of recurrent genomic alterations. Proc Natl Acad Sci USA 2004; 101: 1039–1044.
Sellmann L, Gesk S, Walter C, Ritgen M, Harder L, Martin-Subero JI et al. Trisomy 19 is associated with trisomy 12 and mutated IGHV genes in B-chronic lymphocytic leukaemia. Br J Haematol 2007; 138: 217–220.
Athanasiadou A, Stamatopoulos K, Gaitatzi M, Stavroyianni N, Fassas A, Anagnostopoulos A . Recurrent cytogenetic findings in subsets of patients with chronic lymphocytic leukemia expressing IgG-switched stereotyped immunoglobulins. Haematologica 2008; 93: 473–474.
Martin-Subero JI, Ibbotson R, Klapper W, Michaux L, Callet-Bauchu E, Berger F et al. A comprehensive genetic and histopathologic analysis identifies two subgroups of B-cell malignancies carrying a t(14;19)(q32;q13) or variant BCL3-translocation. Leukemia 2007; 21: 1532–1544.
Chapiro E, Radford-Weiss I, Bastard C, Luquet I, Lefebvre C, Callet-Bauchu E et al. The most frequent t(14;19)(q32;q13)-positive B-cell malignancy corresponds to an aggressive subgroup of atypical chronic lymphocytic leukemia. Leukemia 2008; 22: 2123–2127.
Acknowledgements
This work was supported by the Greek Ministry of Health; the ENosAI project (code 09SYN-13-880), co-funded by the EU and the Greek General Secretariat for Research and Technology; the Nordic Cancer Union, the Swedish Cancer Society and the Swedish Medical Research Council.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no conflict of interest.
Additional information
Author contributions
Rachel Ibbotson and Anastasia Athanasiadou performed research, analyzed the data and wrote the paper. Lesley-Ann Sutton, Zadie Davis, Anne Gardiner, Panagiotis Baliakas and Rebeqa Gunnarsson performed research. Achilles Anagnostopoulos and Gunnar Juliusson supervised research. Richard Rosenquist, David Oscier and Kostas Stamatopoulos designed the study, supervised research and wrote the paper.
Supplementary Information accompanies the paper on the Leukemia website
Supplementary information
Rights and permissions
About this article
Cite this article
Ibbotson, R., Athanasiadou, A., Sutton, LA. et al. Coexistence of trisomies of chromosomes 12 and 19 in chronic lymphocytic leukemia occurs exclusively in the rare IgG-positive variant. Leukemia 26, 170–172 (2012). https://doi.org/10.1038/leu.2011.186
Published:
Issue Date:
DOI: https://doi.org/10.1038/leu.2011.186
This article is cited by
-
Metaphase Cytogenetics in Chronic Lymphocytic Leukemia
Current Genetic Medicine Reports (2016)