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Bone marrow stem cell mobilization in stroke: a ‘bonehead’ may be good after all!

Leukemia volume 25, pages 1674–1686 (2011)Cite this article

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Abstract

Mobilizing bone cells to the head, astutely referred to as ‘bonehead’ therapeutic approach, represents a major discipline of regenerative medicine. The last decade has witnessed mounting evidence supporting the capacity of bone marrow (BM)-derived cells to mobilize from BM to peripheral blood (PB), eventually finding their way to the injured brain. This homing action is exemplified in BM stem cell mobilization following ischemic brain injury. Here, I review accumulating laboratory studies implicating the role of therapeutic mobilization of transplanted BM stem cells for brain plasticity and remodeling in stroke.

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Acknowledgements

I extend appreciation to Ms Loren E Glover who provided excellent technical assistance in the final preparation of the manuscript. CVB is supported by James and Esther King Foundation for Biomedical Research Program 1KG01-33966 and NIH R01 5R01NS071956-02, and received research grant support for his projects on bone marrow stem cell therapy for stroke from SanBio Inc., Celgene Cellular Therapeutics, KMPHC and NeuralStem Inc. Some of the stem cell therapy thematic discussions originated from NINDS UO1 5U01NS055914-04.

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    C V Borlongan

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Borlongan, C. Bone marrow stem cell mobilization in stroke: a ‘bonehead’ may be good after all!. Leukemia 25, 1674–1686 (2011). https://doi.org/10.1038/leu.2011.167

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