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MOZ–TIF2-mediated destruction of CBP/p300 is blocked by calpain inhibitor 2

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  1. Troke PJ, Kindle KB, Collins HM, Heery DM . MOZ fusion proteins in acute myeloid leukaemia. Biochem Soc Symp 2006; 73: 23–39.

    CAS  Article  Google Scholar 

  2. Deguchi K, Ayton PM, Carapeti M, Kutok JL, Snyder CS, Williams IR et al. MOZ-TIF2-induced acute myeloid leukemia requires the MOZ nucleosome binding motif and TIF2-mediated recruitment of CBP. Cancer Cell 2003; 3: 259–271.

    CAS  Article  Google Scholar 

  3. Kindle KB, Troke PJ, Collins HM, Matsuda S, Bossi D, Bellodi C et al. MOZ-TIF2 inhibits transcription by nuclear receptors and p53 by impairment of CBP function. Mol Cell Biol 2005; 25: 988–1002.

    CAS  Article  Google Scholar 

  4. Huntly BJ, Shigematsu H, Deguchi K, Lee BH, Mizuno S, Duclos N et al. MOZ-TIF2, but not BCR-ABL, confers properties of leukemic stem cells to committed murine hematopoietic progenitors. Cancer Cell 2004; 6: 587–596.

    CAS  Article  Google Scholar 

  5. Collins HM, Kindle KB, Matsuda S, Ryan CM, Troke PJ, Kalkhoven E et al. MOZ-TIF2 alters cofactor recruitment and histone modification at the RARβ2 promoter: differential effects of MOZ fusion proteins on CBP- and MOZ-dependent activators. J Biol Chem 2006; 281: 17124–17133.

    CAS  Article  Google Scholar 

  6. Matsuda S, Harries JC, Viskaduraki M, Troke PJ, Kindle KB, Ryan CM et al. A conserved α-helical motif mediates the binding of diverse nuclear proteins to the SRC1 interaction domain of CBP. J Biol Chem 2004; 279: 14055–14064.

    CAS  Article  Google Scholar 

  7. Waters L, Yue B, Veverka V, Renshaw P, Bramham J, Matsuda S et al. Structural diversity in p160/CREB-binding protein coactivator complexes. J Biol Chem 2006; 281: 14787–14795.

    CAS  Article  Google Scholar 

  8. Rouaux C, Jokic N, Mbebi C, Boutillier S, Loeffler JP, Boutillier AL . Critical loss of CBP/p300 histone acetylase activity by caspase-6 during neurodegeneration. EMBO J 2003; 22: 6537–6549.

    CAS  Article  Google Scholar 

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This work was supported by the Association of International Cancer Research (KBK), Leukaemia & Lymphoma Research (HMC), Cancer Research UK and the Wellcome Trust. Our thanks are due to Prof. Saverio Minucci (Institute of Oncology, Milan), Dr. Paolo Salomoni (UCL Cancer Institute) and our colleagues in the Gene Regulation Group for advice, reagents, technical assistance and useful discussions. We acknowledge receipt of a travel bursary to KBK from the European Association for Cancer Research.

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Correspondence to D M Heery.

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Kindle, K., Collins, H. & Heery, D. MOZ–TIF2-mediated destruction of CBP/p300 is blocked by calpain inhibitor 2. Leukemia 24, 1359–1361 (2010).

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