Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Original Article
  • Published:

Risk factors and associated diseases among preterm infants with isolated lenticulostriate vasculopathy

Journal of Perinatology volume 36, pages 775–778 (2016)Cite this article

Subjects

Abstract

Objective:

To determine the prevalence, risk factors and diseases associated with isolated lenticulostriate vasculopathy (LSV) among preterm infants.

Study Design:

Medical records of 84 preterm infants (gestational age (GA) 25 to 34 weeks) with isolated LSV in a case–control retrospective study over a period of 6.5 years were reviewed and compared with matched control infants. LSV was defined as ‘early’ if it was documented in head ultrasound (HUS) before or on the fifth day of life and ‘late’ if it was not present in the first HUS and recorded later during neonatal hospitalization.

Results:

A 3.9% prevalence of LSV was recorded among preterm infants (GA⩽34 weeks). Study and control groups were similar for all maternal parameters, neonatal outcomes and length of hospitalization. Infants with late LSV had more neonatal complications than control infants and were born with younger GA and lower birth weight in comparison to infants with early LSV. More infants with late LSV needed mechanical ventilation, were diagnosed with bronchopulmonary dysplasia and were hospitalized longer in comparison to infants with early LSV. Urine cytomegalovirus was negative in the entire study group.

Conclusions:

No risk factors or specific associated morbidities were identified among preterm infants with early isolated LSV. Infants with late isolated LSV were younger and had overall increased associated morbidities. Long-term outcome studies are needed to determine LSV impact.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Similar content being viewed by others

References

  1. Mittendorf R, Kuban K, Pryde PG, Gianopoulos JG, Yousefzadeh D . Antenatal risk factors associated with the development of lenticulostriate vasculopathy (LSV) in neonates. J Perinatol 2005; 25 (2): 101–107.

    Article  Google Scholar 

  2. Coley BD, Rusin JA, Boue DR . Importance of hypoxic/ischemic conditions in the development of cerebral lenticulostriate vasculopathy. Pediatr Radiol 2000; 30 (12): 846–855.

    Article  CAS  Google Scholar 

  3. Leijser LM, Steggerda SJ, de Bruïne FT, van Zuijlen A, van Steenis A, Walther FJ et al. Lenticulostriate vasculopathy in very preterm infants. Arch Dis Child Fetal Neonatal Ed 2010; 95 (1): F42–F46.

    Article  CAS  Google Scholar 

  4. Makhoul IR, Eisenstein I, Sujov P, Soudack M, Smolkin T, Tamir A et al. Neonatal lenticulostriate vasculopathy: further characterisation. Arch Dis Child Fetal Neonatal Ed 2003; 88 (5): F410–F414.

    Article  CAS  Google Scholar 

  5. El Ayoubi M, de Bethmann O, Monset-Couchard M . Lenticulostriate echogenic vessels: clinical and sonographic study of 70 neonatal cases. Pediatr Radiol 2003; 33 (10): 697–703.

    Article  Google Scholar 

  6. Hemachandra AH, Oravec D, Collin M, Tafari N, Mhanna MJ . Early and late postnatal identification of isolated lenticulostriate vasculopathy in preterm infants: associated findings. J Perinatol 2003; 23 (1): 20–23.

    Article  CAS  Google Scholar 

  7. Rumack CM, Drose JA. Neonatal and infant brain imaging. In: Rumack CM, Wilson SR, Charboneau JW (eds). Perinatal Neuroradiology. Elsevier Mosby: St. Louis, MO, USA, 2005, p 1624.

  8. de Jong EP, Lopriore E, Vossen AC, Steggerda SJ, Te Pas AB, Kroes AC et al. Is routine TORCH screening warranted in neonates with lenticulostriate vasculopathy? Neonatology 2010; 97 (3): 274–278.

    Article  CAS  Google Scholar 

  9. Teele RL, Hernanz-Schulman M, Sotrel A . Echogenic vasculature in the basal ganglia of neonates: a sonographic sign of vasculopathy. Radiology 1988; 169 (2): 423–427.

    Article  CAS  Google Scholar 

  10. Wang HS, Kuo MF . Sonographic lenticulostriate vasculopathy in infancy with tic and other neuropsychiatric disorders developed after 7 to 9 years of follow-up. Brain Dev 2003; 25 (Suppl 1): S43–S47.

    Article  Google Scholar 

  11. Kashman N, Kramer U, Stavorovsky Z, Shefer-Kaufmann N, Harel S, Mimouni FB et al. Prognostic significance of hyperechogenic lesions in the basal ganglia and thalamus in neonates. J Child Neurol 2001; 16 (8): 591–594.

    Article  CAS  Google Scholar 

  12. Wang HS, Kuo MF, Chang TC . Sonographic lenticulostriate vasculopathy in infants: some associations and a hypothesis. AJNR Am J Neuroradiol 1995; 16 (1): 97–102.

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neonatology, The Edmond and Lily Safra Children's Hospital, Sheba Medical Center, Tel Hashomer, Israel

    A Maayan-Metzger, L Leibovitch, I Schushan-Eisen, M Soudack & T Strauss

  2. Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel

    A Maayan-Metzger, L Leibovitch, I Schushan-Eisen, M Soudack & T Strauss

Authors
  1. A Maayan-Metzger
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. L Leibovitch
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. I Schushan-Eisen
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M Soudack
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. T Strauss
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to A Maayan-Metzger.

Ethics declarations

Competing interests

The authors declare no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Maayan-Metzger, A., Leibovitch, L., Schushan-Eisen, I. et al. Risk factors and associated diseases among preterm infants with isolated lenticulostriate vasculopathy. J Perinatol 36, 775–778 (2016). https://doi.org/10.1038/jp.2016.67

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/jp.2016.67

This article is cited by

Search

Advanced search

Quick links