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Chlamydia trachomatis IgG3 seropositivity is associated with gastroschisis

Journal of Perinatology volume 35, pages 930–934 (2015)Cite this article

Subjects

Abstract

Objective:

To investigate the association between Chlamydia trachomatis (CT) infection seropositivity and gastroschisis.

Study design:

In this case–control study we enrolled pregnant women either prenatally diagnosed with gastroschisis (cases, n=33) or with a normal ultrasound (controls, n=66). Both groups attended the University of Utah's Maternal Fetal Medicine Diagnostic Center for their diagnostic ultrasound or because of a community obstetrician referral. Participants completed a structured interview on potential risk factors. Anti-CT immunoglobulin (IgG)1 and IgG3 were measured by a CT elementary body enzyme-linked immunosorbent assay.

Result:

Median age at sexual debut was lower and reported sexual partner number higher in cases compared with controls. Risk factors for gastroschisis included having ⩾3 sexual partners (odds ratio (OR)=3.3, 95% CI 1.2, 9.4), change in partner from the previous pregnancy (OR=3.6, 95% CI 0.9, 13.9) and anti-CT IgG3 seropositivity (age-adjusted OR=3.9, 95% CI: 1.1, 13.2).

Conclusion:

Anti-CT IgG3 seropositivity was associated with greater than a threefold risk for gastroschisis.

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Acknowledgements

This study was supported by a Cooperative Agreement (Number U01DD000490) from the Centers for Disease Control and Prevention to the Utah Center for Birth Defects Research and Prevention participating in the National Birth Defects Prevention Study. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the Centers for Disease Control and Prevention.

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Authors and Affiliations

  1. Department of Pediatrics, Division of Medical Genetics, University of Utah School of Medicine, Salt Lake City, UT, USA,

    M L Feldkamp, E Y Enioutina, L D Botto, S Krikov & J L B Byrne

  2. Department of Obstetrics and Gynecology, University of Utah School of Medicine, Salt Lake City, UT, USA,

    J L B Byrne

  3. Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA,

    W M Geisler

Authors
  1. M L Feldkamp
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  2. E Y Enioutina
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  3. L D Botto
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  4. S Krikov
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  5. J L B Byrne
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  6. W M Geisler
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Corresponding author

Correspondence to M L Feldkamp.

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The authors declare no conflict of interest.

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Feldkamp, M., Enioutina, E., Botto, L. et al. Chlamydia trachomatis IgG3 seropositivity is associated with gastroschisis. J Perinatol 35, 930–934 (2015). https://doi.org/10.1038/jp.2015.115

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