Abstract
The epidemiology, etiology and outcome of neonatal sepsis are changing over time. While monitoring longitudinal trends in neonatal sepsis in our institution, we encountered a case of late-onset neonatal sepsis due to Leclercia adecarboxylata. A Gram-negative rod previously not encountered in the clinical setting, L. adecarboxylata has recently emerged as a human pathogen, primarily in immunosuppressed patients. This report describes the clinical and laboratory features of this case of late-onset L. adecarboxylata sepsis, and reviews significant features of infection associated with this emerging pathogen.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Similar content being viewed by others
References
Bizzarro MJ, Raskind C, Baltimore RS, Gallagher PG . Seventy-five years of neonatal sepsis at Yale: 1928–2003. Pediatrics 2005; 116: 595–602.
Forrester JD, Adams J, Sawyer RG . Leclercia adecarboxylata bacteremia in a trauma patient: case report and review of the literature. Surg Infect 2012; 13: 63–66.
Stock I, Burak S, Wiedemann B . Natural antimicrobial susceptibility patterns and biochemical profiles of Leclercia adecarboxylata strains. Clin Microbiol Infect 2004; 10: 724–733.
Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ . Basic local alignment search tool. J Mol Biol 1990; 215: 403–410.
Leclerc H . Etude biochimique d'enterobacteriaceae pigmentees. Ann Inst Pasteur 1962; 102: 726–741.
Tamura KSR, Kosako Y, Yoshizaki E . Leclercia adecarboxylata gen.nov., comb. Nov., formely known as Escherichia adecarboylata. Curr Microbiol 1986; 13: 179–184.
Cai M, Dong X, Wei J, Yang F, Xu D, Zhang H et al. Isolation and identification of Leclercia adecarboxylate in clinical isolates in China. Wei Sheng Wu Xue Bao 1992; 32: 119–123.
Davenport P, Land KJ . Isolation of Leclercia adecarboxylata from the blood culture of an asymptomatic platelet donor. Transfusion 2007; 47: 1816–1819.
Dalamaga M, Pantelaki M, Karmaniolas K, Daskalopoulou K, Migdalis I . Isolation of Leclercia adecarboxylata from blood and burn wound after a hydrofluoric acid chemical injury. Burns 2009; 35: 443–445.
Shah A, Nguyen J, Sullivan LM, Chikwava KR, Yan AC, Treat JR . Leclercia adecarboxylata cellulitis in a child with acute lymphoblastic leukemia. Pediatr Dermatol 2011; 28: 162–164.
Mazzariol A, Zuliani J, Fontana R, Cornaglia G . Isolation from blood culture of a Leclercia adecarboxylata strain producing an SHV-12 extended-spectrum beta-lactamase. J Clin Microbiol 2003; 41: 1738–1739.
Fattal O, Deville JG . Leclercia adecarboxylata peritonitis in a child receiving chronic peritoneal dialysis. Pediatr Nephrol 2000; 15: 186–187.
Longhurst CA, West DC . Isolation of Leclercia adecarboxylata from an infant with acute lymphoblastic leukemia. Clin Infect Dis 2001; 32: 1659.
Myers KA, Jeffery RM, Lodha A . Late-onset Leclercia adecarboxylata bacteraemia in a premature infant in the NICU. Acta Paediatr 2012; 101: e37–e39.
Otani EBD . Leclercia adecarboxylata isolated from blood culture. Clin Microbiol Newslett 1991; 13: 157–158.
Acknowledgements
This Study was supported in part by a grant from the NICHD, T32 HD007094.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no conflict of interest.
Rights and permissions
About this article
Cite this article
Nelson, M., Maksimova, Y., Schulz, V. et al. Late-onset Leclercia adecarboxylata sepsis in a premature neonate. J Perinatol 33, 740–742 (2013). https://doi.org/10.1038/jp.2013.34
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1038/jp.2013.34