Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • Perinatal/Neonatal Case Presentation
  • Published:

Perinatal/Neonatal Case Presentation

Late-onset Leclercia adecarboxylata sepsis in a premature neonate

Abstract

The epidemiology, etiology and outcome of neonatal sepsis are changing over time. While monitoring longitudinal trends in neonatal sepsis in our institution, we encountered a case of late-onset neonatal sepsis due to Leclercia adecarboxylata. A Gram-negative rod previously not encountered in the clinical setting, L. adecarboxylata has recently emerged as a human pathogen, primarily in immunosuppressed patients. This report describes the clinical and laboratory features of this case of late-onset L. adecarboxylata sepsis, and reviews significant features of infection associated with this emerging pathogen.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1

Similar content being viewed by others

References

  1. Bizzarro MJ, Raskind C, Baltimore RS, Gallagher PG . Seventy-five years of neonatal sepsis at Yale: 1928–2003. Pediatrics 2005; 116: 595–602.

    Article  Google Scholar 

  2. Forrester JD, Adams J, Sawyer RG . Leclercia adecarboxylata bacteremia in a trauma patient: case report and review of the literature. Surg Infect 2012; 13: 63–66.

    Article  Google Scholar 

  3. Stock I, Burak S, Wiedemann B . Natural antimicrobial susceptibility patterns and biochemical profiles of Leclercia adecarboxylata strains. Clin Microbiol Infect 2004; 10: 724–733.

    Article  CAS  Google Scholar 

  4. Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ . Basic local alignment search tool. J Mol Biol 1990; 215: 403–410.

    Article  CAS  Google Scholar 

  5. Leclerc H . Etude biochimique d'enterobacteriaceae pigmentees. Ann Inst Pasteur 1962; 102: 726–741.

    CAS  Google Scholar 

  6. Tamura KSR, Kosako Y, Yoshizaki E . Leclercia adecarboxylata gen.nov., comb. Nov., formely known as Escherichia adecarboylata. Curr Microbiol 1986; 13: 179–184.

    Article  Google Scholar 

  7. Cai M, Dong X, Wei J, Yang F, Xu D, Zhang H et al. Isolation and identification of Leclercia adecarboxylate in clinical isolates in China. Wei Sheng Wu Xue Bao 1992; 32: 119–123.

    CAS  PubMed  Google Scholar 

  8. Davenport P, Land KJ . Isolation of Leclercia adecarboxylata from the blood culture of an asymptomatic platelet donor. Transfusion 2007; 47: 1816–1819.

    Article  Google Scholar 

  9. Dalamaga M, Pantelaki M, Karmaniolas K, Daskalopoulou K, Migdalis I . Isolation of Leclercia adecarboxylata from blood and burn wound after a hydrofluoric acid chemical injury. Burns 2009; 35: 443–445.

    Article  CAS  Google Scholar 

  10. Shah A, Nguyen J, Sullivan LM, Chikwava KR, Yan AC, Treat JR . Leclercia adecarboxylata cellulitis in a child with acute lymphoblastic leukemia. Pediatr Dermatol 2011; 28: 162–164.

    Article  Google Scholar 

  11. Mazzariol A, Zuliani J, Fontana R, Cornaglia G . Isolation from blood culture of a Leclercia adecarboxylata strain producing an SHV-12 extended-spectrum beta-lactamase. J Clin Microbiol 2003; 41: 1738–1739.

    Article  CAS  Google Scholar 

  12. Fattal O, Deville JG . Leclercia adecarboxylata peritonitis in a child receiving chronic peritoneal dialysis. Pediatr Nephrol 2000; 15: 186–187.

    Article  CAS  Google Scholar 

  13. Longhurst CA, West DC . Isolation of Leclercia adecarboxylata from an infant with acute lymphoblastic leukemia. Clin Infect Dis 2001; 32: 1659.

    Article  CAS  Google Scholar 

  14. Myers KA, Jeffery RM, Lodha A . Late-onset Leclercia adecarboxylata bacteraemia in a premature infant in the NICU. Acta Paediatr 2012; 101: e37–e39.

    Article  CAS  Google Scholar 

  15. Otani EBD . Leclercia adecarboxylata isolated from blood culture. Clin Microbiol Newslett 1991; 13: 157–158.

    Article  Google Scholar 

Download references

Acknowledgements

This Study was supported in part by a grant from the NICHD, T32 HD007094.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to P G Gallagher.

Ethics declarations

Competing interests

The authors declare no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Nelson, M., Maksimova, Y., Schulz, V. et al. Late-onset Leclercia adecarboxylata sepsis in a premature neonate. J Perinatol 33, 740–742 (2013). https://doi.org/10.1038/jp.2013.34

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/jp.2013.34

Keywords

Search

Quick links