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  • Original Article
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Possible counter effect in newborns of 1936A>G (I646V) polymorphism in the AKAP10 gene encoding A-kinase-anchoring protein 10

Journal of Perinatology volume 32, pages 230–234 (2012)Cite this article

Subjects

Abstract

Objective:

Cyclic adenosine monophosphate/protein kinase A (PKA) is important in embryonic development. The human AKAP10 gene is polymorphic: 1936A>G results in changes to a PKA-binding domain and increased targeting to mitochondria. Previous studies found G1936 as ‘deleterious’ in adults, and this study investigates whether this holds true in preterm birth.

Study Design:

Study group consisted of 80 preterm newborns (PTNs) born before the 38th gestation week. Control group consisted of 123 full-term healthy newborns born after the 37th gestation week with uncomplicated pregnancies. Genomic DNA was extracted from umbilical blood and AKAP10 genotypes were identified by PCR/restriction enzyme.

Result:

Significant differences in frequencies of 1936A>G genotypes/alleles between both groups were found. PTNs had increased frequency (55%) of AA homozygotes (odds ratio, AA versus AG+GG: 2.63 (95% confidence interval: 1.33 to 5.20), P=0.006) after adjustments: mothers with previous PTNs, smoking, first pregnancy, first delivery and Cesarean section.

Conclusion:

Results suggest G1936 is preventative factor against preterm birth, in contrast with previously asserted negative effects in adults.

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Acknowledgements

This study was funded entirely by the Pomeranian Medical University, Szczecin, Poland.

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Authors and Affiliations

  1. Department of Neonatal Diseases, Pomeranian Medical University, Szczecin, Poland

    B Łoniewska, A Kordek & J Rudnicki

  2. Department of Clinical and Molecular Biochemistry, Pomeranian Medical University, Szczecin, Poland

    J S Clark, M Kaczmarczyk, A Biñczak-Kuleta & A Ciechanowicz

  3. Department of Medical Biology, Pomeranian Medical University, Szczecin, Poland

    G Adler

  4. Department of Pediatrics, Endocrinology, Diabetology, Metabolic Diseases and Children's Cardiology, Pomeranian Medical University, Szczecin, Poland

    A Horodnicka-Józwa & G Dawid

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  1. B Łoniewska
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Correspondence to J S Clark.

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Łoniewska, B., Clark, J., Kaczmarczyk, M. et al. Possible counter effect in newborns of 1936A>G (I646V) polymorphism in the AKAP10 gene encoding A-kinase-anchoring protein 10. J Perinatol 32, 230–234 (2012). https://doi.org/10.1038/jp.2011.85

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