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Secondary adrenal insufficiency in sick neonates: should we treat with ACTH?

Journal of Perinatology volume 29, page 526 (2009)Cite this article

I read with great interest the article by Fernandez et al.1 published in a recent issue of the Journal of Perinatology describing ACTH (adrenocorticotropic hormone) and cortisol responses in critically ill neonates. I have two concerns regarding the manuscript.

First, in view of the findings of responsive adrenal gland to ACTH in sick neonates (secondary adrenal insufficiency), would better practice be to treat these infants with ACTH or corticotropin-releasing hormone rather than hydrocortisone?

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References

  1. Fernandez EF, Montman R, Watterberg KL . ACTH and cortisol response to critical illness in term and late preterm neonates. J Perinatol 2008; 28: 797–802.

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  1. Department of Pediatrics, Rockford Memorial Hospital, Rockford, IL, USA

    S Manzar

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  1. S Manzar
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Correspondence to S Manzar.

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Manzar, S. Secondary adrenal insufficiency in sick neonates: should we treat with ACTH?. J Perinatol 29, 526 (2009). https://doi.org/10.1038/jp.2009.45

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