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  • Perinatal/Neonatal Case Presentation
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Perinatal/Neonatal Case Presentation

An extremely low body weight infant born to a mother with measles

Abstract

The incidence of measles epidemics has decreased recently owing to the development and widespread use of measles vaccine in the United States of America and Europe. However, repeated measles epidemics have been reported in Japan. Here, the authors report a case of an extremely low body weight infant (ELBWI) whose mother had a measles virus infection. Real-time PCR was performed on the infant's blood and urine samples and skin, nasal secretion, and anal swabs, as well as on the mother's breast milk, blood samples and throat swabs. The infant was found to be positive for measles virus by PCR, but not immunoglobulin M positive. An earlier report showed that there were no such cases in which the patient was found to be positive for measles virus by real-time PCR but was not infected by the measles virus.

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References

  1. Nakata Y, Nakayama T, Ide Y, Kizu R, Koinuma G, Bamba M . Measles virus genome detected up to four months in a case of congenital measles. Acta Paediatri 2002; 91: 1263–1265.

    Article  CAS  Google Scholar 

  2. Kugel RB . AMA. J Dis Child 1957; 93 (3): 306–307.

    CAS  Google Scholar 

  3. Siegel M, Fuerst HT . Low birth weight and maternal virus diseases. A prospective study of rubella, measles, mumps, chickenpox, and hepatitis. JAMA 1966; 197 (9): 680–684.

    Article  CAS  Google Scholar 

  4. Jason E, Eberhart-Phillips MD . Measles in pregnancy: a descriptive study of 58 cases. Obstet Gynecol 1993; 82: 797–801.

    Google Scholar 

  5. Linder N, Tallen-Gopzani E, German B, Duvdevani P, Ferber A, Sirota L . Placental transfer of measles antibodies: effect of gestational age and maternal vaccination status. Vaccine 2004; 22: 1509–1514.

    Article  CAS  Google Scholar 

  6. de Muralt G . Maturation of cellular and humoral immunity. In: Stave U. (ed). Perinatal Physiology. Plenum: New York, 1978.

    Google Scholar 

  7. Christensen PE, Schmidt H, Bang HO, Andersen V, Jordal B, Jensen O . An epidemic of measles in southern Greenland, 1951 Measles in virgin soil. The epidemic proper. Acta Med Scand 1953; 144 (6): 450–454.

    Article  CAS  Google Scholar 

  8. Koi H, Zhang J, Makrigiannakis A, Getsios S, MacCalman CD, Straus JF III, et al. Syncytiotrophoblast is a barrier to maternal-fetal transmission of herpes simplex virus. Biol Reprod 2005; 67: 1572–1579.

    Article  Google Scholar 

  9. Ohyama M, Fukui T, Tanaka Y, Kato K, Hoshino R, Sugawara T et al. Measles virus infection in the placenta of monozygotic twin. Mod Pathol 2001; 14 (12): 1300–1303.

    Article  CAS  Google Scholar 

  10. Bhat P, Anderson DA . Hepatitis B virus translocates across a trophoblastic barrier. J Virol 2007; 81: 7200–7207.

    Article  CAS  Google Scholar 

  11. Plumet S, Gelier D . Optimized SYBR green real-timePCR assay to quantify the absolute copy number of measles virus RNAs using gene specific primers. J Virol Methods 2005; 128 (1–2): 79–87.

    Article  CAS  Google Scholar 

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Correspondence to H Go.

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Go, H., Hashimoto, K., Imamura, T. et al. An extremely low body weight infant born to a mother with measles. J Perinatol 30, 146–148 (2010). https://doi.org/10.1038/jp.2009.111

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