This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 digital issues and online access to articles
$119.00 per year
only $9.92 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Choi M, Scholl UI, Yue P, Björklund P, Zhao B, Nelson-Williams C et al. K+ channel mutations in adrenal aldosterone-producing adenomas and hereditary hypertension. Science 2011; 331: 768–772.
Zheng FF, Zhu LM, Nie AF, Li XY, Lin JR, Zhang K et al. Clinical characteristics of somatic mutations in Chinese patients with aldosterone-producing adenoma. Hypertension 2015; 65: 622–628.
Lenzini L, Rossitto G, Maiolino G, Letizia C, Funder JW, Rossi GP . A meta-analysis of somatic KCNJ5 K(+) channel mutations in 1636 patients with an aldosterone-producing adenoma. J Clin Endocrinol Metab 2015; 100: E1089–E1095.
Williams TA, Lenders JW, Burrello J, Beuschlein F, Reincke M . KCNJ5 mutations: sex, salt and selection. Horm Metab Res 2015; 47: 953–958.
Dutta RK, Söderkvist P, Gimm O . Genetics of primary hyperaldosteronism. Endocr Relat Cancer 2016; 23: R437–R454.
Oki K, Plonczynski MW, Luis Lam M, Gomez-Sanchez EP, Gomez-Sanchez CE . Potassium channel mutant KCNJ5 T158A expression in HAC-15 cells increases aldosterone synthesis. Endocrinology 2012; 153: 1774–1782.
Murthy M, Xu S, Massimo G, Wolley M, Gordon RD, Stowasser M et al. Role for germline mutations and a rare coding single nucleotide polymorphism within the KCNJ5 potassium channel in a large cohort of sporadic cases of primary aldosteronism. Hypertension 2014; 63: 783–789.
Roux B . Ion conduction and selectivity in K(+) channels. Annu Rev Biophys Biomol Struct 2005; 34: 153–171.
Tauber P, Penton D, Stindl J, Humberg E, Tegtmeier I, Sterner C et al. Pharmacology and pathophysiology of mutated KCNJ5 found in adrenal aldosterone-producing adenomas. Endocrinology 2014; 155: 1353–1362.
Kuppusamy M, Caroccia B, Stindl J, Bandulik S, Lenzini L, Gioco F et al. A novel KCNJ5-insT149 somatic mutation close to, but outside, the selectivity filter causes resistant hypertension by loss of selectivity for potassium. J Clin Endocrinol Metab 2014; 99: E1765–E1773.
Acknowledgements
The study was funded by grants from Youth Program (81500324) and State Key Program (81230071, 91539202) of the National Natural Science foundation of China; Shanghai Municipal Health Bureau (20134109).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no conflict of interest.
Additional information
Supplementary Information accompanies this paper on the Journal of Human Hypertension website
Supplementary information
Rights and permissions
About this article
Cite this article
Zheng, FF., Zhu, LM., Zhou, WL. et al. A novel somatic mutation 145–147delETEinsK in KCNJ5 increases aldosterone production. J Hum Hypertens 31, 756–759 (2017). https://doi.org/10.1038/jhh.2017.50
Published:
Issue Date:
DOI: https://doi.org/10.1038/jhh.2017.50
This article is cited by
-
Primary aldosteronism: molecular medicine meets public health
Nature Reviews Nephrology (2023)