Abstract
Associations between high serum uric acid (SUA) levels and high blood pressure (BP), as well as between SUA levels and metabolic syndrome (MetS) have already been reported. The aim of the study was to investigate the relationship between the components of MetS with the SUA levels as also between SUA and apolipoproteins A1 and B (apoA1 and apoB) ratio in hypertensive patients. A total of 2577 consecutive hypertensive patients (1193 male and 1384 female) aged 57.5±13.3 years, were enrolled in our research. Samples were taken to measure SUA, glucose, triglycerides, high density lipoprotein (HDL-C), components of the MetS and apoA1 and apoB. The study population was divided into two groups: group A: SUA levels above normal range (men ⩾7 mg dl−1, women ⩾6 mg dl−1) and group B: SUA levels within normal range. In the overall study population, SUA levels showed a statistically significant correlation with waist circumference (WC; r=0.293, P<0.000), triglycerides (r=0.197, P<0.000), glucose (r=0.085, P<0.000), apoB/apoA1 (r=0.136, P<0.000) and HDL-C (r=−0.235, P<0,001). In newly diagnosed untreated hypertensive patients there was also a statistically significant correlation of SUA levels with WC (r=0.331, P<0.001), triglycerides (r=0.228, P<0.001) apoB/apoA1 ratio (r=0.202, P<0.001) and HDL-C (r=−0.278, P<0.001). In hyperurecemic hypertensives there was a statistically significant correlation between SUA levels with WC (r=0.168, P=0.007), apoB/apoA1 ratio (r=0.256, P=0.003) and HDL-C (r=−0.202, P<0.001). SUA levels correlate significantly with all the components of MetS, as well as with the risk factor apoB/apoA1 ratio, in hypertensive patients.
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References
Desideri G, Castaldo G, Lombardi A, Mussap M, Testa A, Pontremoli R et al. Is it time to revise the normal range of serum uric acid levels? Eur Rev Md Pharmacol Sci 2014; 18 (9): 1295–1306.
Fang J, Alderman MH . Serum uric acid and cardiovascular mortality the NHANES I epidemiologic follow-up study, 1971-1992. National Health and Nutrition Examination Survey. JAMA 2000; 283 (18): 2404–2410.
Ofori SN, Odia OJ . Serum uric acid and target organ damage in essential hypertension. Vasc Health Risk Manag 2014; 10: 253–261.
Mule G, Riccobene R, Castiglia A, D’Ignoto F, Ajello E, Geraci G et al. Relationships between mild hyperuricaemia and aortic stiffness in untreated hypertensive patients. Nutr Metab Cardiovasc Dis 2014; 24 (7): 744–750.
Wilson PW, D’Agostino RB, Parise H, Sullivan L, Meigs JB . Metabolic syndrome as a precursor of cardiovascular disease and type 2 diabetes mellitus. Circulation 2005; 112 (20): 3066–3072.
Knowles JW, Reaven G . Hyperuricemia: the unintended consequence of insulin resistance/compensatory hyperinsulinemia. J Intern Med 2014; 276 (2): 196–198.
Ciarla S, Struglia M, Giorgini P, Striuli R, Necozione S, Properzi G et al. Serum uric acid levels and metabolic syndrome. Arch Physiol Biochem 2014; 120 (3): 119–122.
Billiet L, Doaty S, Katz JD, Velasquez MT . Review of hyperuricemia as new marker for metabolic syndrome. ISRN Rheumatol 2014; 2014: 852954.
Fabbrini E, Serafini M, Colic Baric I, Hazen SL, Klein S . Effect of plasma uric acid on antioxidant capacity, oxidative stress, and insulin sensitivity in obese subjects. Diabetes 2014; 63 (3): 976–981.
Lu M, Lu Q, Zhang Y, Tian G . ApoB/apoA1 is an effective predictor of coronary heart disease risk in overweight and obesity. J Biomed Res 2011; 25 (4): 266–273.
Panayiotou A, Griffin M, Georgiou N, Bond D, Tyllis T, Tziakouri-Shiakalli C et al. ApoB/ApoA1 ratio and subclinical atherosclerosis. Int Angiol 2008; 27 (1): 74–80.
Morrison JA, Glueck CJ, Daniels SR, Horn PS, Wang P . Determinants of ApoB, ApoA1, and the ApoB/ApoA1 ratio in healthy schoolgirls, prospectively studied from mean ages 10 to 19 years: the Cincinnati National Growth and Health Study. Metabolism 2012; 61 (10): 1377–1387.
Kostapanos MS, Christogiannis LG, Bika E, Bairaktari ET, Goudevenos JA, Elisaf MS et al. Apolipoprotein B-to-A1 ratio as a predictor of acute ischemic nonembolic stroke in elderly subjects. J Stroke Cerebrovasc Dis 2010; 19 (6): 497–502.
Wang SH, Sun ZL, Ruan XZ, Guo YJ, Wang Y, Jin H et al. Dyslipidaemia among diabetic patients with ischemic stroke in a Chinese hospital. Chin Med J 2009; 122 (21): 2567–2572.
Peristein TS, Gumieniak O, Williams GH, Sparrow D, Vokonas PS, Gaziano M et al. Uric acid and the development of hypertension. Hypertension American Heart association 2006; 48: 1031.
Jossa F, Farinaro E, Panico S, Krogh V, Celentano E, Galasso R et al. Serum uric acid and hypertension: the Olivetti heart study. J Hum Hypertens 1994; 8 (9): 677–681.
Dawson J, Jeemon P, Hetherington L, Judd C, Hastie C, Schulz C et al. Serum uric acid level, longitudinal blood pressure, renal function, and long-term mortality in treated hypertensive patients. Hypertension 2013; 62: 105–111.
Forman JP, Choi H, Curhan GC . Plasma uricacid level and risk for incident hypertension among men. J Am Soc Nephrol 2007; 18 (1): 287–292.
Sierra-Johnson J, Romero-Corral A, Somers VK, Lopez-Jimenez F, Walldius G, Hamsten A et al. ApoB/apoA-I ratio: an independent predictor of insulin resistance in US non-diabetic subjects. Eur Heart J 2007; 28 (21): 2637–2643.
Lind L, Vessby B, Sundström J . The apolipoprotein B/AI ratio and the metabolic syndrome independently predict risk for myocardial infarction in middle-aged men. Arterioscler Thromb Vasc Biol 2006; 26 (2): 406–410.
Sierra-Johnson J, Fisher RM, Romero-Corral A, Somers VK, Lopez-Jimenez F, Ohrvik J et al. Concentration of apolipoprotein B is comparable with the apolipoprotein B/apolipoprotein A-I ratio and better than routine clinical lipid measurements in predicting coronary heart disease mortality: findings from a multi-ethnic US population. Eur Heart J 2009; 30 (6): 710–717.
Savas Erdeve S, Simsek E, Dallar Y, Biyikli Z . Utility of ApoB/ApoA1 ratio for the prediction of cardiovascular risk in children with metabolic syndrome. Indian J Pediatr 2010; 77 (11): 1261–1265.
Smith J, Al-Amri M, Sniderman A, Cianflone K . Leptin and adiponectin in relation to body fat percentage, waist to hip ratio and the apoB/apoA1 ratio in Asian Indian and Caucasian men and women. Nutr Metab 2006; 3: 18.
Sabino AP, De Oliveira Sousa M, Moreira Lima L, Dias Ribeiro D, Sant’Ana Dusse LM, Das Graças Carvalho M et al. ApoB/ApoA-I ratio in young patients with ischemic cerebral stroke or peripheral arterial disease. Transl Res 2008; 152 (3): 113–118.
Galvan AQ, Natali A, Baldi S, Frascerra S, Sanna G, Ciociaro D et al. Effect of insulin on uric acid excretion in humans. Am J Physiol 1995; 268: E1–E5.
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Papavasileiou, M., Karamanou, A., Kalogeropoulos, P. et al. Uric acid blood levels and relationship with the components of metabolic syndrome in hypertensive patients. J Hum Hypertens 30, 414–417 (2016). https://doi.org/10.1038/jhh.2015.53
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DOI: https://doi.org/10.1038/jhh.2015.53
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