Abstract
Lipid accumulation product (LAP), an index calculated by using triglyceride level and waist circumference, has been shown to predict hypertension, diabetes and cardiovascular disease. Alcohol is known to influence blood pressure and blood lipids. The aim of this study was to clarify the relationships among alcohol intake, LAP and hypertension. The subjects, middle-aged Japanese men (n=21 572), were divided into non-, light (<22 g ethanol per day), moderate (⩾22 and<44 g ethanol per day) and heavy (⩾44 g ethanol per day) drinkers. The relationships between alcohol intake and LAP and between LAP and hypertension were investigated. There were U- and J-shaped relationships between alcohol intake and LAP in subjects with and without hypertension, respectively. The adjusted odds ratios with their 95% confidence intervals for hypertension in subjects with vs subjects without high LAP were 3.04 (2.69–3.43, P<0.01), 2.32 (1.92–2.81, P<0.01), 2.10 (1.89–2.33, P<0.01) and 2.11 (1.87–2.38, P<0.01) in non-, light, moderate and heavy drinkers, respectively. Thus, the positive association between LAP and hypertension is weaker in drinkers than in nondrinkers. The results suggest that light-to-moderate alcohol drinking reduces LAP level in patients with hypertension and attenuates the relation of LAP to hypertension.
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References
Corrao G, Rubbiati L, Bagnardim V, Zambon A, Poikolainen K . Alcohol and coronary heart disease: a meta-analysis. Addiction 2000; 95: 1505–1523.
Ronksley PE, Brien SE, Turner BJ, Mukamal KJ, Ghali WA . Association of alcohol consumption with selected cardiovascular disease outcomes: a systematic review and meta-analysis. BMJ 2011; 342: d671.
Savolainen MJ, Kesäniemi YA . Effects of alcohol on lipoproteins in relation to coronary heart disease. Curr Opin Lipidol 1995; 6: 243–250.
Ellison RC, Zhang Y, Qureshi MM, Knox S, Arnett DK, Province MA . Investigators of the NHLBI Family Heart Study. Lifestyle determinants of high-density lipoprotein cholesterol: the National Heart, Lung, and Blood Institute Family Heart Study. Am Heart J 2004; 147: 529–535.
Salem RO, Laposata M . Effects of alcohol on hemostasis. Am J Clin Pathol 2005; 123 (Suppl): S96–S105.
Klatsky AL . Alcohol and cardiovascular disease—more than one paradox to consider. Alcohol and hypertension: does it matter? Yes. J Cardiovasc Risk 2003; 10: 21–24.
Taylor B, Irving HM, Baliunas D, Roerecke M, Patra J, Mohapatra S et al. Alcohol and hypertension: gender differences in dose-response relationships determined through systematic review and meta-analysis. Addiction 2009; 104: 1981–1990.
Van de Wiel A . The effect of alcohol on postprandial and fasting triglycerides. Int J Vasc Med 2012; 2012: 862504.
Klop B, do Rego AT, Cabezas MC . Alcohol and plasma triglycerides. Curr Opin Lipidol 2013; 24: 321–326.
Hokanson JE, Austin MA . Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level: a meta-analysis of population-based prospective studies. J Cardiovasc Risk 1996; 3: 213–219.
Labreuche J, Touboul PJ, Amarenco P . Plasma triglyceride levels and risk of stroke and carotid atherosclerosis: a systematic review of the epidemiological studies. Atherosclerosis 2009; 203: 331–345.
Sowers JR . Obesity as a cardiovascular risk factor. Am J Med 2003; 115 (Suppl 8A): 37S–41S.
Suter PM . Is alcohol consumption a risk factor for weight gain and obesity? Crit Rev Clin Lab Sci 2005; 42: 197–227.
Yeomans MR . Alcohol, appetite and energy balance: is alcohol intake a risk factor for obesity? Physiol Behav 2010; 100: 82–89.
Kahn HS . The "lipid accumulation product" performs better than the body mass index for recognizing cardiovascular risk: a population-based comparison. BMC Cardiovasc Disord 2005; 5: 26.
Wehr E, Pilz S, Boehm BO, März W, Obermayer-Pietsch B . The lipid accumulation product is associated with increased mortality in normal weight postmenopausal women. Obesity (Silver Spring) 2011; 19: 1873–1880.
Ioachimescu AG, Brennan DM, Hoar BM, Hoogwerf BJ . The lipid accumulation product and all-cause mortality in patients at high cardiovascular risk: a PreCIS database study. Obesity (Silver Spring) 2010; 18: 1836–1844.
Kahn HS . The lipid accumulation product is better than BMI for identifying diabetes: a population-based comparison. Diabetes Care 2006; 29: 151–153.
Bozorgmanesh M, Hadaegh F, Azizi F . Diabetes prediction, lipid accumulation product, and adiposity measures; 6-year follow-up: Tehran lipid and glucose study. Lipids Health Dis 2010; 9: 45.
Wakabayashi I . Relationship between alcohol intake and lipid accumulation product in middle-aged men. Alcohol Alcohol 2013; 48: 535–542.
Shimomura T, Wakabayashi I . Inverse associations between light-to-moderate alcohol intake and lipid-related indices in patients with diabetes. Cardiovasc Diabetol 2013; 12: 104.
Chobanian AV, Bakris GL, Black HR, Cushman WC, Green LA, Izzo JL Jr et alNational High Blood Pressure Education Program Coordinating Committee. The Seventh Report of the Joint National Committee on Prevention, Detection, Evaluation, and Treatment of High Blood Pressure: the JNC 7 report. JAMA 2003; 289: 2560–2572.
European Society of Hypertension-European Society of Cardiology Guidelines Committee. 2003 European Society of Hypertension-European Society of Cardiology guidelines for the management of arterial hypertension. J Hypertens 2003; 21: 1011–1053.
Ogihara T, Kikuchi K, Matsuoka H, Fujita T, Higaki J, Horiuchi M et alJapanese Society of Hypertension Committee. The Japanese Society of Hypertension Guidelines for the Management of Hypertension (JSH 2009). Hypertens Res 2009; 32: 3–107.
Anonymous. Metabolic syndrome-definition and diagnostic criteria in Japan. J Jpn Soc Int Med 2005; 94: 794–809 (in Japanese).
Wakabayashi I, Daimon T . A strong association between lipid accumulation product and diabetes mellitus in Japanese women and men. J Atheroscler Thromb 2014; 21: 282–288.
Wakabayashi I . Relationship between smoking and metabolic syndrome in men with diabetes mellitus. Metab Syndr Relat Disord 2014; 12: 70–78.
Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults. Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, And Treatment of High Blood Cholesterol In Adults (Adult Treatment Panel III). JAMA 2001; 285: 2486–2497.
Anonymous; Health, Labour and Welfare Statistics Association. Annual Statistical Report of National Health Conditions. J Health Welfare Stat 2013; 60: 101 (in Japanese).
McLaughlin T, Abbasi F, Cheal K, Chu J, Lamendola C, Reaven G . Use of metabolic markers to identify overweight individuals who are insulin resistant. Ann Intern Med 2003; 139: 802–809.
Sumner AE, Finley KB, Genovese DJ, Criqui MH, Boston RC . Fasting triglyceride and the triglyceride-HDL cholesterol ratio are not markers of insulin resistance in African Americans. Arch Intern Med 2005; 165: 1395–1400.
Mostafa SA, Davies MJ, Morris DH, Yates T, Srinivasan BT, Webb D et al. The association of the triglyceride-to-HDL cholesterol ratio with insulin resistance in White European and South Asian men and women. PLoS ONE 2012; 7: e50931.
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Wakabayashi, I. Light-to-moderate alcohol intake reduces lipid accumulation product and attenuates its relation to hypertension. J Hum Hypertens 29, 359–365 (2015). https://doi.org/10.1038/jhh.2014.97
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DOI: https://doi.org/10.1038/jhh.2014.97
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