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Circulating microRNAs as potential non-invasive biomarkers for the early detection of hypertension-related stroke

Journal of Human Hypertension volume 28, pages 288–291 (2014)Cite this article

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Abstract

Hypertension is one of the most important risk and modifiable factors for stroke. Crucial in managing the cerebrovascular damage caused by long-lasting and inadequately treated hypertension is not only lowering arterial blood pressure but also early predicting subtypes of hypertension-related stroke and applying more effective interventions. Accumulating evidence suggested that circulating microRNAs (miRNAs) could be developed as biomarkers for early recognition of the onset of a variety of diseases. The role of miRNAs has been extensively reviewed, involving cardiac hypertrophy, hypertensive heart failure, kidney failure and renal fibrosis. miRNA research in stroke is still in its infancy, although there are few literatures reviewing the role of miRNAs in the processes of hypertension-related stroke. This review summarizes current advances in miRNAs regulation of critical pathogenic process underlying hypertension, ischemic stroke and hemorrhagic stroke, and highlights the potential of using circulating miRNAs as noninvasive biomarkers for the early detection of hypertension-related stroke.

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Acknowledgements

This work will be kindly supported by grants from the Municipal Science and Technology and Information Technology Department of Guangzhou (132000567) and the Scientific and Technological Department of Guangdong Province (20130319c).

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Authors and Affiliations

  1. Department of Neurology, Zhujiang Hospital, Southern Medical University, Guangzhou, China

    W Y Li, J Jin, J Chen, Y Guo & S Tan

  2. KingMed Diagnostics Group, KingMed College of Laboratory Medicine, Guangzhou Medical University, Guangzhou, China

    J Tang

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Correspondence to S Tan.

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Li, W., Jin, J., Chen, J. et al. Circulating microRNAs as potential non-invasive biomarkers for the early detection of hypertension-related stroke. J Hum Hypertens 28, 288–291 (2014). https://doi.org/10.1038/jhh.2013.94

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