Transcription factor 7-like 2 (TCF7L2) has been shown to be associated with type 2 diabetes mellitus in multiple ethnic groups. Regarding the Asian population, Horikoshi et al. (Diabetologia 50:747–751, 2007) and Hayashi et al. (Diabetologia 50:980–984, 2007) reported that single nucleotide polymorphisms (SNPs) in TCF7L2 were associated with type 2 diabetes in the Japanese population, while contradictory results were reported for Han Chinese populations. The aim of this study was to investigate the associations of the TCF7L2 gene with type 2 diabetes using a relatively large sample size: 2,214 Japanese individuals with type 2 diabetes and 1,873 normal controls. The minor alleles of rs7903146, rs11196205, and rs12255372 showed significant associations with type 2 diabetes (OR = 1.48, P = 2.7 × 10−4; OR = 1.39, P = 4.6 × 10−4; OR = 1.70, P = 9.8 × 10−5, respectively) in the combined sample sets. However, neither rs11196218 nor rs290487 showed a significant association. These results indicate that TCF7L2 is an important susceptibility gene for type 2 diabetes in the Japanese population.

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    • Yuichiro Yamada

    Present address: Department of Internal Medicine, Akita University School of Medicine, Akita, Japan


  1. Division of Diabetes, Metabolism and Endocrinology, Department of Internal Medicine, Kobe University Graduate School of Medicine, 7-5-1 Kusunoki-cho, Chuo-ku, Kobe 650-0017, Japan

    • Kazuaki Miyake
    • , Yushi Hirota
    •  & Masato Kasuga
  2. Department of Diabetes and Endocrinology Division of Molecule and Structure, Gifu University School of Medicine, Gifu, Japan

    • Yukio Horikawa
    •  & Jun Takeda
  3. Laboratory of Medical Genomics, Biosignal Genome Resource Center, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, Japan

    • Yukio Horikawa
  4. Department of Metabolic Diseases, Graduate School of Medicine, University of Tokyo, Tokyo, Japan

    • Kazuo Hara
    •  & Takashi Kadowaki
  5. Department of Metabolic Disorder, Research Institute, International Medical Center of Japan, Tokyo, Japan

    • Kazuki Yasuda
  6. Department of Molecular and Genetic Medicine, Ehime University Graduate School of Medicine, Ehime, Japan

    • Haruhiko Osawa
    •  & Hideichi Makino
  7. The First Department of Medicine, Wakayama Medical University, Wakayama, Japan

    • Hiroto Furuta
    •  & Kishio Nanjo
  8. Department of Metabolic Medicine, Graduate School of Medicine, Osaka University, Osaka, Japan

    • Kazuya Yamagata
  9. Division of Molecular Metabolism and Diabetes, Tohoku University Graduate School of Medicine, Sendai, Japan

    • Yoshinori Hinokio
    •  & Yoshitomo Oka
  10. Department of Medicine, Diabetes Center, Tokyo Women's Medical University, Tokyo, Japan

    • Naoko Iwasaki
    •  & Yasuhiko Iwamoto
  11. Kansai Electric Power Hospital, Osaka, Japan

    • Yutaka Seino
  12. Division of Endocrinology and Metabolism Department of Medicine, Shiga University of Medical Science, Shiga, Japan

    • Hiroshi Maegawa
    •  & Atsunori Kashiwagi
  13. Department of Molecular Genetics, Medical Institute of Bioregulation, Kyushu University, Fukuoka, Japan

    • Ken Yamamoto
  14. Department of Human Genetics, Graduate School of Medicine, University of Tokyo, Tokyo, Japan

    • Katsushi Tokunaga
  15. Department of Diabetes and Clinical Nutrition, Kyoto University School of Medicine, Kyoto, Japan

    • Yuichiro Yamada
    •  & Yutaka Seino


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Corresponding author

Correspondence to Masato Kasuga.

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