Abstract
We present a report of the parental ages (n = 865) and parental origin of meiotic nondisjunction (n = 236) that are likely to show a predisposition in the etiology of Down syndrome (DS). Chromosomal analysis, performed over a 20-year period, on 1001 Down syndrome subjects, revealed pure trisomy 21 karyotype in 880 subjects (87.92%), mosaic trisomy karyotype in 77 (7.69%), and translocation karyotype in 44 (4.39%). The mean maternal age was found to be 30.34 years, and mean paternal age was 31.04 years. Nondisjunctional error was 79.24% maternal and 20.76% paternal. The findings of the study revealed the significant contribution of advanced parental age and increased maternal meiotic nondisjunctional error to the origin of trisomy 21 Down syndrome.
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Received: December 21, 2000 / Accepted: March 5, 2001
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Jyothy, A., Kumar, K., Rao, G. et al. Parental age and the origin of extra chromosome 21 in Down syndrome. J Hum Genet 46, 347–350 (2001). https://doi.org/10.1007/s100380170071
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DOI: https://doi.org/10.1007/s100380170071
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