Abstract
Nramp1 (natural resistance-associated macrophage protein 1), encoding a polytropic integral membrane protein, was isolated as a candidate of the mouse Lsh/Ity/Bcg locus, which regulates macrophage activation for antimicrobial activity against intracellular pathogens. The NRAMP2 gene was cloned from human genome as a homologue of NRAMP1. We found a polymorphic dinucleotide repeat in the third intron of the NRAMP2 gene. This polymorphism will be a useful genetic marker to study disease associated with susceptibility to infection with intracellular pathogens.
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Received: August 13, 1999 / Accepted: August 19, 1999
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Kishi, F., Fujishima, S. & Tabuchi, M. Dinucleotide repeat polymorphism in the third intron of the NRAMP2/DMT1 gene. J Hum Genet 44, 425–427 (1999). https://doi.org/10.1007/s100380050195
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DOI: https://doi.org/10.1007/s100380050195