Summary
An interstitial deletion, del(11)(q14q22), found in a female infant was examined by fluorescencein situ hybridization with cosmid DNA markers mapped on the long arm of chromosome 11. Three cosmids mapped on 11q14.1-11q22.1 region were not hybridized to the del(11) chromosome, while all the other DNA markers mapped on 11cen-11q14.1 and 11q23.1-11 qter region gave hybridization signals on the del(11) chromosome. Cytogenetic analysis after R-banding confirmed an apparent deletion of 11q14-q22, but containing a small R-negative band, a part of 11q22.3 and/or 11q14.1, in the middle part of del(11) chromosome. The karyotype thus was determined to be 46, XX, del(11)(q14.1q22.3).
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Hori, Ta., Masuno, M., Wakazono, A. et al. Interstitial deletion of the long arm of chromosome 11 determined by fluorescencein situ hybridization. Jap J Human Genet 38, 219–224 (1993). https://doi.org/10.1007/BF01883713
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DOI: https://doi.org/10.1007/BF01883713