Summary
Restriction fragment length polymorphisms were studied among the Japanese using 13 polymorphic DNA probes on the X chromosome. For 6 probes (pPA4B, cpX203, p58-1, pHPGK-7e, cpX289 and 7b) the allelic frequencies were the same as those for Caucasians, but they were quite different (p<0.01) for 4 probes (dic56, pOTC (MspI), pTAK8B and pXG-16 (HindIII)). No polymorphisms were observed for 4 probes (pG95α1-7dIII/RI (n (chromosome number studied)=54), pXG-16 (TaqI) (n=50), p8 (n=108), and pXG-17 (n=76). These results suggest that not a small number of DNA probes currently available are useless for linkage analysis in Japan.
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Antonarakis, S.E., Waber, P.G., Kittur, S.D., Patel, A.S., Kazazian, H.H., Mellis, M.A., Counts, R.B., Stamatoyannopoulos, G., Bowie, E.J.W., Fass, D.N., Pittman, D.D., Wozney, J.M. and Toole, J.J. 1985. Hemophilia A. Detection of molecular defects and of carriers by DNA analysis.New Engl. J. Med. 313: 842–848.
Arveiler, B., Hofker, M.H., Bergen, A.A., Pearson, P. and Mandel, J.L. 1987. APst I RFLP detected by probe cpx73 (DXS159) in Xq11-q12.Nucleic Acids Res. 15: 5903.
Guesella, J.F., Wexler, N.S., Conneally, P.M., Naylor, S.L., Anderson, M.A., Tanzi, R.E., Witkins, P.C., Ottina, K., Wallance, M.R., Sakaguchi, A.Y., Young, A.B., Shoulson, I., Bonilla, E. and Mortin, J.B. 1983. A polymorphic DNA marker genetically linked to Huntington's disease.Nature 306: 234–238.
Haneda, M., Kobayashi, M., Maegawa, H. and Shigeta, Y. 1986. Low frequency of the large insertion in the human insulin gene in Japanese.Diabetus 35: 115–118.
Kojima, T., Tanimoto, M., Kamiya, T., Obata, Y., Takeuchi, T., Ohno, R., Kurachi, K. and Saito, H. 1987. Possible absence of common polymorphisms in coagulation factor IX gene in Japanese subjects.Blood 69: 349–352.
Lubahn, D.B., Lord, S.T., Bosco, J., Kirshtein, J., Jeffries, O.J., Parker, N., Levtzow, C., Silverman, L.M. and Graham, J.B. 1987. Population genetics of coagulant factor IX: Frequencies of two DNA polymorphisms in five ethnic groups.Am. J. Hum. Genet. 40: 527–536.
Nussbaum, R.L., Boggs, B.A., Beaudet, A.L., Doyle, S., Potter, J.L. and O'Brien, W.E. 1986. New mutation and prenatal diagnosis in ornithine transcarbamylase deficiency.Am. J. Hum. Genet. 39: 438–451.
Ogasawara, N. 1988. Hypoxanthine guanine phosphoribosyl transferase deficiency: Lesch-Nyhan syndrome.Protein, Nucleic Acid and Enzyme (in Japanese)33: 601–605.
Prochownik, E.V., Antonarakis, S., Bauer, K.A., Rosenberg, R.D., Fearson, E.R. and Orkin, S.H. 1983. Molecular heterogeneity of inherited antithrombin deficiency.New Engl. J. Med. 308: 1549–1552.
Shimmoto, M., Tsuji, A. and Suzuki, Y. 1988. Restriction fragment length polymorphisms on the short arm of X chromosome among the Japanese population.Jpn. J. Human Genet. 34: 123–128.
Suehiro, K., Tanimoto, M., Hamaguchi, M., Kojima, T., Takamatsu, J., Ogata, K., Kamiya, T. and Saito, H. 1988. Carrier detection of Japanese hemophilia A by use of three intragenic and two extragenic factor VIII DNA probes: A study of 24 kindreds.J. Lab. Clin. Med. 112: 314–318.
Suzuki, N., Nagao, T. and Nakahori, Y. 1988. Carrier detection of hemophilia A in the Japanese population by use of four intragenic and extragenic RFLPs.Jpn. J. Clin. Hematol. (in Japanese)29: 19–26.
Taga, T., Shirahase, W., Shimada, M., Kurokawa, K. and Ueyama, H. 1989. Restriction fragment length polymorphisms on the q24–q28 region of X chromosome among Japanese population.Jpn. J. Human Genet. 34: 123–128.
Wainscoat, J.S., Hill, A.V.S., Boyce, A.L., Flint, J., Hernandez, M., Thein, S.L., Old, J.M., Lynch, J.R., Falusi, A.G., Wetherall, D.J. and Clegg, J.B. 1986. Evolutionary relationships of human populations from an analysis of nuclear DNA polymorphisms.Nature 319: 491–493.
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Ueyama, H., Shirahase, W., Taga, T. et al. Restriction fragment length polymorphisms of X chromosome among Japanese population. Jap J Human Genet 34, 285–289 (1989). https://doi.org/10.1007/BF01929210
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DOI: https://doi.org/10.1007/BF01929210