Summary
Lymphocytes from four patients with tuberous sclerosis (TS) and four normal controls were studied for sister chromatid exchanges (SCEs) and chromosome aberrations in gamma-ray irradiated cultures. There was no significant difference between SCE frequencies of TS lymphocytes and those of control lymphocytes at all doses examined (1, 2, and 4 Gy). However, chromosome aberrations in TS lymphocytes were significantly higher than those in the normal controls at the highest dose (4 Gy) (p<0.05).
Similar content being viewed by others
Article PDF
References
Goto, K., Maeda, S., Kano, Y., and Sugiyama, T. 1978. Factors involved in differential Giemsastaining of sister chromatids.Chromosoma 66:351–359.
Hafez, M., Abd, El-Nabi, S.M., EL-Wehedi, G., and AL-Tonbary, Y. 1986. Enhanced response to the induction of sister chromatid exchange by gamma radiation in neurofibromatosis.Cancer 57:1937–1940.
Iijima, S., Higurashi, M., Takeshita, T., and Funahashi, M. 1985. Spontaneous and mitomycin-C induced sister chromatid exchanges in cells from patients with tuberous sclerosis.Proc. Jpn. Acad. 61B:32–34.
Latt, S.A., Schreck, R.R., Loveday, K.S., Dougherty, C.P., and Shuler, C.F., 1980. Sister chromatid exchanges. InAdvances in Human Genetics, Vol. 10, Harris, H. and Hirschhorn, K., eds., Plenum Press, New York and London, pp. 267–331.
Paterson, M.C., Sell, B.M., Smith, B.P., and Bech-Hansen, T. 1982. Impaired colony-forming ability following irradiation of skin fibroblasts from tuberous sclerosis patients.Radiat. Res. 90:260–270.
Roos, R.P. 1977. An immunological and cytogenetic investigation of tuberous sclerosis.Annu. Neurol. 1:192–194.
Scudiero, D.A., Moshell, A.N., Scarpinato, R.G., Meyer, S.A., Clatterbuck, B.E., Tarone, R.E., and Robbins, J.H. 1981. Lymphoblastoid lines and skin fibroblasts from patients with tuberous sclerosis are abnormally sensitive to ionizing radiation and to a radiomimetic chemical.J. Invest. Dermatol. 78:234–238.
Suzuki, Y. 1977. Cytological study in tuberous sclerosis.J. Pediatr. Practice (Japan) 40:353–358 (in Japanese).
Yoshida, Y., Hayashi, A., and Arima, M. 1985. Rapid rejoining of X-ray induced DNA singlestrand breaks in tuberous sclerosis fibroblasts.Mutat. Res. 146:211–218.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Iijima, S., Higurashi, M., Takeshita, T. et al. Radiation-induced chromosome aberrations and sister chromatid exchanges in lymphocytes from patients with tuberous sclerosis. Jap J Human Genet 33, 349–353 (1988). https://doi.org/10.1007/BF02032865
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF02032865
Keywords
This article is cited by
-
Bleomycin-induced chromosomal damage in tuberous sclerosis
The Japanese Journal of Human Genetics (1990)