Summary
Restriction fragment length polymorphisms were studied among the Japanese population using 13 polymorphic DNA probes on the short arm of X chromosome. The calculated molecular sizes of polymorphic bands for the probes 782, pXUT23 and 754 were larger than those in previous reports from North America and Europe, and their frequency distribution was markedly different for the probes C7, pERT87-8 and XJ5.1. The probe pD2 did not show any polymorphism in the present study for the Japanese population. The genetic significance of these differences was discussed.
Similar content being viewed by others
Article PDF
References
Akita, Y., Ohno, S., Goto, J., Nakano, I., Takatsu, M., Sugita, H., and Suzuki, K. 1987. Diagnosis of Duchenne and Becker muscular dystrophies by DNA polymorphism.Jpn. J. Human Genet. 32:71–82.
Bakker, E., Hofker, M.H., Goor, N., Mandel, J.L., Wrogemann, K., Davies, K.E., Kunkel, L.M., Willard, H.F., Fenton, W.A., Sandkuyl, L., Majoor-Krakauer, D., Essen, A.J.v., Jahoda, M.G.J., Sachs, E.S., van Ommen, G.J.B., and Pearson, P.L. 1985. Prenatal diagnosis and carrier detection on Duchenne muscular dystrophy with closely linked RFLPs.Lancet 1: 655–658.
Blin, N. and Stafford, D.E. 1976. A general method for isolation of high molecular weight DNA from eukaryotes.Nucleic Acids Res. 3:2303–2308.
Burghes, A.H.M., Logan, C., Hu, X., Belfall, B., Worton, R.G., and Ray, P.N. 1987. A cDNA clone from the Duchenne/Becker muscular dystrophy gene.Nature 328:434–437.
Drayna, D. and White, R. 1985. The genetic linkage map of the human X chromosome.Science 230:753–758.
Gusella, J.F., Wexler, N.S., Conneally, P.M., Naylor, S.L., Anderson, M.A., Tanzi, R.E., Watkins, P.C., Ottina, K., Wallance, M.R., Sakaguchi, A.Y., Young, A.B., Shoulson, I., Bonilla, E., and Martin, J.B. 1983. A polymorphic DNA marker genetically linked to Huntington's disease.Nature 306:234–238.
Kunkel, L.M. and co-authors. 1986. Analysis of deletions in DNA from patients with Becker and Duchenne muscular dystrophy.Nature 322:73–77.
Lidsky, A.S., Ledley, F.D., Dilella, A.G., Kwok, S.C.M., Daiger, S.P., Robson, K.J.H., and Woo, S.L.C. 1985. Extensive restriction site polymorphisms at human phenylalanine hydroxylase locus and application in prenatal diagnosis of phenylketonuria.Am. J. Hum. Genet. 37:619–634.
Monaco, A.P., Neve, R.L., Colletti-Feener, C., Bertelson, C.J., Kurnit, D.M., and Kunkel, L.M. 1986. Isolation of candidate cDNAs for portions of the Duchenne muscular dystrophy gene.Nature 322:646–650.
Paul, H., Galton, D., and Stocks, J. 1987. DNA polymorphic patterns and haplotype arrangements of the apo A-1, apo C-III, apo A-IV gene cluster in different ethnic groups.Hum. Genet. 75:264–268.
Royer-Pokora, B., Kunkel, L.M., Monaco, A.M., Goff, S.G., Newburger, P.E., Baehner, R.L., Cole, F.S., Curnutte, J.T., and Orkin, S.H. 1986. Cloning the gene for an inherited human disorder—chronic granulomatous disease—on the basis of its chromosomal location.Nature 322:32–38.
Rozen, R., Fox, J.E., Hack, A.M., Fenton, W.A., Horwich, A.L., and Rosenberg, L.E. 1986. DNA analysis for ornithine transcarbamylase deficiency.J. Inher. Metab. Dis. 9 (S1):49–57.
Shimmoto, M., Tsuji, A., Yang, R.-C., Suzuki, Y., Nomura, Y., and Segawa, M. 1987. Genetic linkage analysis of X-linked inherited disease using restriction fragment length polymorphism—Family studies on Duchenne muscular dystrophy, Becker muscular dystrophy and ornithine transcarbamylase deficiencyNihon Shonika Gakkai Zasshi (Tokyo) 91:3440–3447 (in Japanese).
Shimmoto, M., Tsuji, A., Yang, R.-C., Nomura, Y., Segawa, M., and Suzuki, Y. 1988. DNA deletions and recombinations in the gene locus of X-linked muscular dystrophies.J. Inher. Metab. Dis., in press.
Southern, E.M. 1975. Detection of specific sequence among DNA fragments separated by gel electrophoresis.J. Mol. Biol. 78:503–517.
Thompson, M.W., Ray, P.N., Belfall, B., Duff, C., Logan, C., Oss, I., and Worton, R.G. 1986. Linkage analysis of polymorphisms within the DNA fragment XJ cloned from the breakpoint of an X;21 translocation associated with X-linked muscular dystrophy.J. Med. Genet. 23: 548–555.
White, P.C., New, M.I., and Dupont, B. 1984. HLA-linked congenital adrenal hyperplasia results from a defective gene encoding a cytochrome P-450 specific for steroid 21-hydroxylation.Proc. Natl. Acad. Sci. USA 81:7505–7509.
Wieringa, B., Hustinx, J., Scheres, M., Hofker, M., Schepens, J., Ropers, H.H. and ter Haar, B. 1985. Glycerol kinase deficiency syndrome explained as X-chromosomal deletion.Cytogenet. Cell Genet. 40:777.
Willard, H.F., Skolnick, M.H., Pearson, P.L., and Mandel, J.-L. 1985. Report of the committee on human gene mapping by recombinant DNA techniques.Cytogenet. Cell Genet. 20:366–489.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Shimmoto, M., Tsuji, A. & Suzuki, Y. Restriction fragment length polymorphisms on the short arm of X chromosome among the Japanese population. Jap J Human Genet 33, 333–338 (1988). https://doi.org/10.1007/BF02032863
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF02032863
Keywords
This article is cited by
-
Allele frequencies of intragenic, and 5′ and 3′ markers of the dystrophin gene in Japanese families afflicted with Duchenne or Becker muscular dystrophy
Japanese Journal of Human Genetics (1996)