Summary
Apolipoprotein (apo) CIIISst-I genotypes and apo AIMsp-I genotypes were investigated in 82 unrelated healthy Japanese, using genomic hybridization analysis with a 2.2 kb fragment of the human apo AI gene. The frequencies of theS2 andM2 alleles were 0.34 and 0.40, respectively, and much higher than those in Caucasians. The alleles identified by the apo CIIISst-I and apo AIMsp-I polymorphisms were observed to be in linkage disequilibrium (Δ=0.206±0.012, p<0.001). Three of the four possible haplotypes were identified: the frequencies of the haplotype wereS1−M1=0.604,S2−M2=0.34, andS1−M2=0.055. The data indicate that Japanese are characterized by the common presence of the haplotypeS2−M2 as compared with Caucasians and that the haplotypes identified by the apo CIIISst-I and apo AIMsp-I polymorphisms are useful genetic markers for Japanese.
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Onuki, M., Iwamura, Y., Humphries, S.E. et al. Apolipoprotein AI-CIII gene polymorphisms in a Japanese population. Jap J Human Genet 31, 337–343 (1986). https://doi.org/10.1007/BF01907933
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DOI: https://doi.org/10.1007/BF01907933
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