Summary
Genetic polymorphisms of the complement components C6 and C7 in two Chinese populations (Beijing and Guangzhou) were investigated, using isoelectric focusing and immunoblotting technique. Three common and four rare allotypes of C6 were observed, and one of the rare allotypes was considered to be a new variant. Ten different patterns of C7 observed were classified into three homozygous and seven heterozygous phenotypes, indicating occurrence of four common and a new variant alleles. The new variants of C6 and C7 detected were designated as C6 B21 and C7 6, respectively. There was no statistically significant difference for C6 and C7 allele frequencies between the Beijing and the Guangzhou populations except forC7 *4. TheC7 *4 frequency was shown to be significantly higher in Beijing than in Guangzhou. No significant positive association between C6 and C7 alleles was found.
Similar content being viewed by others
Article PDF
References
Hobart, M.J., Lachmann, P.J., and Alper, C.A. 1975. Polymorphism of human C6. InProtides of the Biological Fluids, Peeters, H. ed., 22nd Colloq., Pergamon Press, Oxford, pp. 575–580.
Hobart, M.J., Joysey, V., and Lachmann, P.J. 1978. Inherited structural variation and linkage relationships of C7.J. Immunogenet. 55: 157–163.
Kunsmann, G., Mauff, G., and Pulverer, G. 1980. C6 polymorphism and rare alleles in Western Germany.Immunobiology 158: 55–59.
Mauff, G., Alper, C.A., Hobart, M.J., Kühnl, P., Kunstmann, G., Meo, T., Olving, J.H., and Rittner, C.H. 1980. Statement on the nomenclature of human C6 polymorphism.Immunobiology 158: 139–143.
Nakamura, S., Ooue, O., and Abe, K. 1984a. Genetic polymorphism of the seventh component of complement in a Japanese population.Hum. Genet. 66: 279–281.
Nakamura, S., Ooue, O., Akiyama, K., and Abe, K. 1984b. Genetic polymorphism of complement C6 and haplotype analysis between C6 and C7 in a Japanese population.Hum. Genet. 68: 138–141.
Nishimukai, H., Kitamura, H., Kishida, T., and Tamaki, Y. 1985. C6 polymorphism in Japanese: Typing by agarose gel isoelectric focusing-immunofixation.Hum. Hered. 35: 30–33.
Nishimukai, H. and Tamaki, Y. 1986. Genetic polymorphism of the seventh component of complement: A new variant.Vox Sang. 51: 60–62.
Olving, J.H., Teisberg, P., and Olaisen, B. 1980. Polymorphism of the sixth component of complement (C6) in Norwegian Lapps.Hum. Hered. 30: 211–214.
Ranford, P.R., Kirk, R.L., and Zimmet, P. 1982. Distribution of complement factors BF, C2 and C6 in the Western Pacific.Acta Anthropogenetica 6: 23–32.
Tokunaga, K., Yukiyama, Y., and Omoto, K. 1983. Polymorphism of the complement component C6 in Japanese.J. Immunogenet. 10: 419–424.
Tokunaga, K., Yamamura, N., and Omoto, K. 1984. An immunoblotting technique for complement C6 typing: Three new variants.Jpn. J. Human Genet. 29: 415–419.
Tokunaga, K., Dewald, G., Omoto, K., and Juji, T. 1986. Family study on the polymorphisms of the sixth and seventh components (C6 and C7) of human complement: Linkage and haplotype analyses.Am. J. Hum. Genet. 39: 414–419.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Zeng, Zm., Tokunaga, K., Omoto, K. et al. Genetic polymorphisms of complement C6 and C7 in two Chinese populations. Jap J Human Genet 31, 263–271 (1986). https://doi.org/10.1007/BF01870757
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01870757