Summary
Two siblings, a two-year-old boy and a one-month-old girl, both showed congenital lymphedema of the feet. The parents were healthy and apparently unrelated, but both were born on Mishima, an island with a population of 1,500, located in the Sea of Japan. The occurrence of lymphedema in these two siblings suggests autosomal recessive inheritance.
Similar content being viewed by others
Article PDF
References
Aagenaes, Φ. 1974. Hereditary recurrent cholestasis with lymphedema. Two new families.Acta Paediatr. Scand. 63: 465–471.
Chynn, K.-Y. 1967. Congenital spinal extradural cyst in two siblings.Am. J. Roentgen. 101: 204–215.
Holmes, L.B., Fields, J.P., and Zabriskie, J.B. 1978. Hereditary late-onset lymphedema.Pediatrics 61: 575–579.
Kääriäinen, H. 1984. Hereditary lymphedema: a new combination of symptoms not fitting into present classifications.Clin. Genet. 26: 254–256.
McKusick, V.A. 1983. Mendelian Inheritance in Man. 6th Ed. Johns Hopkins Univ. Press, Baltimore.
Miller, M. and Motulsky, A.C. 1978. Noonan syndrome in an adult family presenting with chronic lymphedema.Am. J. Med. 65: 379–383.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Kajii, T., Tsukahara, M. Congenital lymphedema in two siblings. Jap J Human Genet 30, 31–34 (1985). https://doi.org/10.1007/BF01883671
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01883671
Keywords
This article is cited by
-
Autosomal recessive lymphedema?
Japanese Journal of Human Genetics (1986)