Summary
Quantitation of C3 and C3 proactivator in a healthy Indian population shows lower levels than in European populations, whereas the levels of all immunoglobulins except IgA are elevated. It is suggested that for the Indian subcontinent the normal IgE level should be taken as 400–500 iu/ml, a figure considerably higher than that in Europe. To assess the possibility of a genetic element in the regional serum protein variation, the association of the immunoglobulin and complement levels with several serum polymorphic characters is examined.
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Agarwal, D.P., Benkmann, H.G., and Goedde, H.W. 1972. Genetic polymorphism of the third component of complement (C3) and levels of B1 C/B1A-globulin in sera of German and Spanish populations.Human Heredity 22:356–361.
Agarwal, D.P., Benkmann, H.G., Goedde, H.W., Rohde, R., Delbruck, H., and Rougemont, A. 1974. Levels of serum B1C/B1A globulin(C3) and its polymorphisms in leprosy patients and healthy control from Ethiopia and Mali.Humangenetik 21:355–359.
Agarwal, D.P., Goedde, H.W., Benkmann, H.G., Flatz, G., Rahimi, A.G., Kaife, S., and Delbruck, H. 1976. Genetic polymorphisms of C3 and serum levels of immunoglobulins, C3, C4 components and C3-proactivator in four different populations of Afghanistan.Human Genetics 33:67–72.
Al-Agidi, S.K., Papiha, S.S., and Roberts D.F. 1977. Immunoglobulin levels in Iraq.Clin. Exp. Immunol. 29:247–255
Alper, C.A., and Propp, R.P. 1968. Genetic polymorphism of the third component of human complement (C3).J. Clin. Investigation 47:2181–2191.
Alper, C.A., and Johnson, A.M. 1969. Immunofixation electrophoresis. A technique for the study of protein polymorphism.Vox Sangous 17:445–452
Arends, T., and Gallango, M.L. 1966. Immunoglobulin levels in blood bank donors of a tropical country. In:Proceedings of Congress of International Society of Blood Transfusion, Sydney 29:332–335.
Bennett, F.J., Kagan, I.G., Barnicot, N.A., and Woodburn, J.C. 1970. Helminth and protozoal parasites of the hadza of Tanzania.Transactions of the Royal Society of Tropical Medicine & Hygiene 64:857–880.
Chopra, V.P. 1970. Studies on serum groups in the Kumaon Region India.Humangenetik 10: 35–43.
Cook, P.J.L. 1975. The genetics of antitrypsin: a family study in England and Scotland.Annals Human Genet. 38:275–287.
Crane, E.G., Pitney, W.R., Hobbs, J.R., and Gunn, C. 1971. Immunoglobulin levels in the Karapit and upper Watut areas of New Guinea, with special reference to the tropical splenomegaly syndrome.Transactions of Royal Society of Tropical Medicine & Hygiene 65:795–807.
Farhud, D., and Walter, H. 1973. Polymorphism of C3 in German, Bulgarian, Iranian and Angola populations.Humangenetik 17:161–164.
Goedde, H.W., Benkmann, H.G., Singh, S., Das, D.M., Chakravartti, M.R., Delbruck, H., and Flatz, G. 1972. Genetic survey in the population of Assam. II. Serum protein and erythrocyte enzyme polymorphism.Human Heredity 22:331–337.
Gupta, R.M., Gupta, V.M., Marwah, S.M., and Gupta, I.M. 1972. Immunology—An interdisciplinary approach.Ind. Prev. Soci. Med. 3:129–131.
Gupta, R.M., Gupta, V.M., and Marwah, S.M. 1975. Serum immunoglobulin G.A and M in Tibetans.Ind. J. Med. Res. 63:1055–1061.
Hitzig, W.H. 1957. Die physiologische entwicklung der immunoglobuline (Gamma unf bela 2 globuline).Helv. Paediat. Acta 12:596.
Hobart, M.J., and Lachmann, P.J. 1976. Allotypes of complement components in man.Transplant Review 32:26–42.
Hobbs, J.R. 1972. Immunoglobulins.Clin. Chem. 14:220–317.
Jarnum, S., Jeejeebhoy, K.N., and Singh, B. 1968. Dysgammaglobulinaema in tropical spure.British Med. J. 4:416–417.
Kellerman, G., and Walter, H. 1970. Investigation on the population genetics of the antitrypsin polymorphism.Humangenetik 10:145–150.
Kulpati, D.D., Padmini, R., and Saha, K. 1976. Serum immunoglobulins in bronchial asthma. In:Proceedings of World Congress on Asthma, Bronchitis and Allied conditions. pp. 188–201.
MacDonald, J.L. 1975. C′3 polymorphism of human complement in North East England.Human Heredity 25:393–397.
Morrow, A., and Motulsky, A.G. 1965. Population genetics of pseudo cholinesterase variants studied with rapid screening method.Clin. Res. 13:266.
Mukherjee, B.N., Das, S.K., and Kellermann, G. 1974. Study of some serum group systems in the Mahishyas and the Muslims in 24 Parganas District West Bengal.Humangenetik 21:27–32.
Neuman, S., and Walter, H. 1968. Frequencies of pseudo cholinesterase variants in Icelanders, Greeks and Pakistanis.Nature (London) 219:950.
Papiha, S.S., Roberts, D.F., Mukerjee, D.P., Singh, S.D., and Malhotra, M. 1978. A Genetic survey in the Bhil tribe of Madhya Pradesh Central India.Am. J. Phys. Anthropol. 49:179–186.
Papiha, S.S., Bernal, J.E., Roberts, D.F., Habebullah, C.M., and Mishra, S.C. 1979. C′3 polymorphisms in certain Indian populations.Human Heredity 29:193–196.
Poulik, M.D. 1957. Starch gel electrophoresis in a discontinuous system of buffers.Nature (London) 180:1477–1479.
Roberts, D.F., Papiha, S.S., Creen, C.K., Chaparwal, B.C., and Mehta, S.C. 1974. Red cell enzymes and other polymorphic systems in Madhya Pradesh Central India.Annals Human Biol. 1:159–174.
Roberts, D.F., Al-Agidi, S.K., and Vincent, K. 1979. Immunoglobulin levels and genetic polymorphisms in the Sukuma of Tanzania.Annals Human Biol. 6:105–110.
Samuel, A.M., Deshpande, V.R., and Singh, B. 1970. Immunoglobulin in normal adult Indians.Ind. J. Med. Res. 58:56–64.
Sehgal, S., and Aikat, B.K. 1970. Serum immunoglobulin G, A, and M in Tibetans.Ind. J. Med. Res. 58:289–296.
Singh, S., Amma, M.K.P., Sareen, K.N., and Goedde, H.W. 1971. A study of the pseudocholinesterase polymorphism among a Punjabi population.Human Heredity 21:388–393.
Stiehm, E.R., and Fudenberg, H.H. 1966. Serum levels of immune globulins in health and disease: A survey.Pediatrics 37:715–727.
Walter, H., Kellermann, G., Bazatzadeh, M., Kruger, J., and Chakravartti, M.R. 1972. Hp, Gc, Cp, Tf, Bg and Pi phenotypes in leprosy patients and healthy controls from West Bengal (India).Humangenetik 14:314–325.
Wells, J.V. 1968. Serum immunoglobulin levels in tropical splenomegaly syndrome in New Guinea.Clin. Exp. Immunol. 3:943–951.
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Papiha, S.S., Bernal, J.E. & Mehrotra, M. Genetic polymorphism of serum proteins and levels of immunoglobulin and complement components in high caste community (Brahmins) of Madhya Pradesh, India. Jap J Human Genet 25, 1–8 (1980). https://doi.org/10.1007/BF01876539
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DOI: https://doi.org/10.1007/BF01876539