Summary
Metabolic properties of haptoglobin 1-1 and 2-2 proteins were investigated by performing turnover studies in normal rabbits in a steady state concerning haptoglobin metabolism. Studies in six rabbits showed that the average plasma half-lives of iodinated haptoglobin 1-1 and 2-2 were similar with values of 2.3 and 2.4 days, respectively. The distribution in the body compartments, however, was significantly different at the equilibrium time and was such that the extravascular compartments contained 57.0% of the total body pool of haptoglobin 1-1, compared only 36.9% in the case of haptoglobin 2-2. These findings suggest that the former protein is higher than the latter in capillary permeability.
These phenomena may be attributable to the difference in the molecular size and/or polymeric structure rather than that in the primary structure between two haptoglobins. The present results would reflex the survival of human haptoglobins in normal man, although the results were obtained by tracing human haptoglobins injected in rabbits. Finally, the biological significance of the type-dependent metabolism of haptoglobins was discussed.
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Tsuda-Kawamura, K., Ogawa, A., Tachibana, N. et al. Type-dependent difference in the metabolism of human haptoglobins. Jap J Human Genet 24, 85–94 (1979). https://doi.org/10.1007/BF01888925
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DOI: https://doi.org/10.1007/BF01888925