Parental consanguineous marriages for the 482 index patients with anencephaly were examined from thekoseki. The rate of first cousin marriages among the parents of anencephalic patients is 1.87%. The rates are 1.5% in urban and 3.8% in rural areas. The difference between the rates of first cousin marriages among parents of anencephalic patients and among the general population is not statistically significant. It seems that the inheritance of anencephaly is not related to a specific number of recessive genes.
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Imaizumi, Y. Some further observations on parental consanguineous marriages of anencephaly in Japan. Jap J Human Genet 22, 49–51 (1977). https://doi.org/10.1007/BF01908285
- General Population
- Cancer Research
- Rural Area
- Index Patient
- Recessive Gene