Summary
Parental consanguineous marriages for the 482 index patients with anencephaly were examined from thekoseki. The rate of first cousin marriages among the parents of anencephalic patients is 1.87%. The rates are 1.5% in urban and 3.8% in rural areas. The difference between the rates of first cousin marriages among parents of anencephalic patients and among the general population is not statistically significant. It seems that the inheritance of anencephaly is not related to a specific number of recessive genes.
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Carter, C. O. 1974. Clues to the aetiology of neural tube malformations.Dev. Med. Child. Neurol. 16: (Suppl. 32): 3–15.
Carter, C. O., David, P. A. and Laurence, K. M. 1968. A family study of major central nervous system malformations in South Wales.J. Med. Genet. 5: 81–106.
Carter, C. O. and Evans, K. 1973. Spina bifida and anencephalus in Greater London.J. Med. Genet. 10: 209–234.
Imaizumi, Y. 1974. Statistical analysis on anencephaly, spina bifida and congenital hydrocephaly in Japan.Jap. J. Human. Genet. 19: 115–135.
Imaizumi, Y. 1976. Distribution of the incidence of anencephaly in Japan.Soc. Biol. 23: 66–72.
Imaizumi, Y., Shinozaki, N. and Aoki, H. 1975. Inbreeding in Japan: Results of a nation-wide study.Jap. J. Human Genet. 20: 91–107.
McKusick, V. A. 1975. Mendelian Inheritance in Man. The Johns Hopkins University Press, Baltimore and London, pp. 837.
Penrose, L. S. 1957. Genetics of anencephaly.J. Ment. Defic. Res. 1: 4–15.
Stevenson, A. C., Johnston, H. A., Stewart, M. I. P. and Golding, D. R. (eds.) 1966. Malformations of structures developed from the neural tube (B1–B7).In Congenital Malformations, Chap. 4, Bull. World Health Org.,34 (Suppl.).
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Imaizumi, Y. Some further observations on parental consanguineous marriages of anencephaly in Japan. Jap J Human Genet 22, 49–51 (1977). https://doi.org/10.1007/BF01908285
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DOI: https://doi.org/10.1007/BF01908285