Original Article

Large-scale preparation of key building blocks for the manufacture of fully synthetic macrolide antibiotics

  • The Journal of Antibiotics volume 71, pages 318325 (2018)
  • doi:10.1038/ja.2017.116
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Abstract

Key building blocks for the production of fully synthetic macrolides have been scaled-up in first time pilot plant and kilo-lab campaigns. These building blocks have supported the discovery of new macrolide antibiotics as well as ongoing preclinical studies.

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Acknowledgements

We thank Dr Yoshi Ichikawa and Dr Ziyang Zhang for helpful discussions during the preparation of this manuscript.

Author information

Affiliations

  1. Process Chemistry, Macrolide Pharmaceuticals Inc., Watertown, MA, USA

    • Philip C Hogan
    • , Chi-Li Chen
    • , Kristen M Mulvihill
    • , Jonathan F Lawrence
    •  & Eric Moorhead
  2. Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, USA

    • Jens Rickmeier
    •  & Andrew G Myers

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Competing interests

The authors declare no conflict of interest.

Corresponding author

Correspondence to Philip C Hogan.

Supplementary information

Supplementary Information accompanies the paper on The Journal of Antibiotics website (http://www.nature.com/ja)