Abstract
The water-soluble N-methoxy-PEG-yl-, N-β-D-glucopyranosyl- and N-β-D-maltosylthioureido aglyco-ristocetin were prepared which, in contrast to ristocetin A, did not induce thrombocyte aggregation. The antibacterial activity of N-β-D-maltosylthioureido aglyco-ristocetin A against MRSA was comparable to that of ristocetin A, while its activity against Enterococcus faecalis (VRE, TSE) is somewhat stronger when compared to those of vancomycin and ristocetin A.
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Sztaricskai, F., Pintér, G., Röth, E. et al. N-Glycosylthioureido Aglyco-ristocetins without Platelet Aggregation Activity. J Antibiot 60, 529–533 (2007). https://doi.org/10.1038/ja.2007.68
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DOI: https://doi.org/10.1038/ja.2007.68
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