Abstract
SMTP-0, a new simple congener of the SMTP nonlysine-analog plasminogen modulators, was isolated from a culture of Stachybotrys microspora. Based on the physico-chemical data, SMTP-0 was shown to be an enantiomer of the antimicrobial compound stachybotrin B. The absolute configuration of SMTP-0 was determined by the modified Mosher method. The stereochemistry was further confirmed using an epimer of SMTP-0. Unlike most SMTPs with an amino acid side chain linked to the nitrogen atom of the lactam moiety, SMTP-0, which lacks the N-linked side chain, showed no plasminogen modulator activity.
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Hasumi, K., Hasegawa, K. & Kitano, Y. Isolation and Absolute Configuration of SMTP-0, a Simplest Congener of the SMTP Family Nonlysine-analog Plasminogen Modulators. J Antibiot 60, 463–468 (2007). https://doi.org/10.1038/ja.2007.60
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DOI: https://doi.org/10.1038/ja.2007.60
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