Abstract
Two new aminophenoxazinone compounds with antitumor activity, elloxazinone A and B, were isolated from the culture filtrate of Streptomyces griseus Acta 2871. Their chemical structures were determined by mass spectrometry, NMR spectroscopy and X-ray analysis. Elloxazinones A and B showed a moderate inhibition of the proliferation of human cells from gastric adenocarcinoma in vitro but a strong inhibition of hepatocellular carcinoma cells whereas elloxazinone B strongly inhibited the proliferation of human breast carcinoma cells.
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†Art. No. 40 in 'Biosynthetic Capacities of Actinomycetes'. Art. No. 39: see ref. 1
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Graf, E., Schneider, K., Nicholson, G. et al. Elloxazinones A and B, New Aminophenoxazinones from Streptomyces griseus Acta 2871†. J Antibiot 60, 277–284 (2007). https://doi.org/10.1038/ja.2007.35
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DOI: https://doi.org/10.1038/ja.2007.35
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