A New Nucleosidyl-peptide Antibiotic, Sansanmycin

Abstract

A new nucleosidyl-peptide antibiotic, sansanmycin, was isolated from an unidentified Streptomyces sp SS. The structure of sansanmycin was elucidated by analyses of its alkaline hydrolysate and spectroscopic analyses. Sansanmycin exhibits antibacterial activity against Mycobacterium tuberculosis H37Ra and Pseudomonas aeruginosa with MIC values of 10 and 12.5 μg/ml, respectively.

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Correspondence to Hongzhang Xu.

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Xie, Y., Chen, R., Si, S. et al. A New Nucleosidyl-peptide Antibiotic, Sansanmycin. J Antibiot 60, 158–161 (2007). https://doi.org/10.1038/ja.2007.16

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Keywords

  • sansanmycin
  • nucleosidyl-peptide
  • antibacterial activity
  • Mycobacterium tuberculosis H37Ra
  • Pseudomonas aeruginosa

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